Overview of Social Cognitive Dysfunctions in Rare Developmental Syndromes With Psychiatric Phenotype

Frontiers in Pediatrics
Aurore MorelCaroline Demily

Abstract

Rare neurodevelopmental syndromes often present social cognitive deficits that may underlie difficulties in social interactions and increase the risk of psychosis or autism spectrum disorders. However, little is known regarding the specificities of social cognitive impairment across syndromes while it remains a major challenge for the care. Our review provides an overview of social cognitive dysfunctions in rare diseases associated with psychiatric symptoms (with a prevalence estimated between 1 in 1,200 and 1 in 25,000 live births: 22q11.2 deletion syndrome, Angelman syndrome, Fragile X syndrome, Klinefelter syndrome, Prader-Willi syndrome, Rett syndrome, Smith-Magenis syndrome, Turner syndrome, and Williams syndrome) and shed some light on the specific mechanisms that may underlie these skills in each clinical presentation. We first detail the different processes included in the generic expression "social cognition" before summarizing the genotype, psychiatric phenotype, and non-social cognitive profile in each syndrome. Then, we offer a systematic review of the social cognitive abilities and the disturbed mechanisms they are likely associated with. We followed the PRISMA process, including the definition of the relevant sear...Continue Reading

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Citations

Nov 9, 2018·Current Opinion in Psychiatry·Jeanne Wolstencroft, David Skuse
Dec 18, 2018·Current Opinion in Psychiatry·Rachel RoystonPatricia Howlin
Mar 20, 2020·Journal of Autism and Developmental Disorders·Katherine EllisHayley Crawford
Feb 16, 2021·BJPsych Open·Maarten OtterClaudia Vingerhoets
Jun 3, 2021·Journal of Clinical Medicine·Jesús CoboAssumpta Caixàs
Oct 14, 2021·Cognitive, Affective & Behavioral Neuroscience·Marie-Noëlle BabinetGeorge A Michael

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