Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C

Comparative Hepatology
Thierry PoynardBernard Hainque

Abstract

SUMMARY: BACKGROUND: Recent studies strongly suggest that due to the limitations and risks of biopsy, as well as the improvement of the diagnostic accuracy of biochemical markers, liver biopsy should no longer be considered mandatory in patients with chronic hepatitis C. In 2001, FibroTest ActiTest (FT-AT), a panel of biochemical markers, was found to have high diagnostic value for fibrosis (FT range 0.00-1.00) and necroinflammatory histological activity (AT range 0.00-1.00). The aim was to summarize the diagnostic value of these tests from the scientific literature; to respond to frequently asked questions by performing original new analyses (including the range of diagnostic values, a comparison with other markers, the impact of genotype and viral load, and the diagnostic value in intermediate levels of injury); and to develop a system of conversion between the biochemical and biopsy estimates of liver injury. RESULTS: A total of 16 publications were identified. An integrated database was constructed using 1,570 individual data, to which applied analytical recommendations. The control group consisted of 300 prospectively studied blood donors. For the diagnosis of significant fibrosis by the METAVIR scoring system, the areas u...Continue Reading

References

Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Jun 30, 2001·The New England Journal of Medicine·S MirzaeiH Kohn
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jules L Dienstag
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kelly A GeboEric B Bass
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nezam H Afdhal
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominique ThabutThierry Poynard
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thierry PoynardJanice Albrecht
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sophie Le CalvezThierry Poynard
Apr 15, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Françoise Imbert-BismutThierry Poynard
Sep 17, 2004·European Journal of Public Health·José M QuintanaIdoia Garay

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Citations

Jan 11, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G UsluerUNKNOWN Study Group
Aug 12, 2009·Hepatology International·Gamal ShihaUNKNOWN Jury of the APASL Consensus Development Meeting 29 January 2008 on Liver Fibrosis With Without Hepatitis B or C
Apr 13, 2007·AIDS Patient Care and STDs·Jaydeep S Kadam, Andrew H Talal
Jul 11, 2006·Journal of Clinical Gastroenterology·Paul J Pockros
Jul 11, 2006·Journal of Clinical Gastroenterology·Ned SnyderJohn Petersen
May 19, 2010·Biomarkers in Medicine·Vlad RatziuThierry Poynard
May 16, 2007·Journal of Viral Hepatitis·M S Sulkowski, Y Benhamou
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·A R J SchneiderW F Caspary
Oct 13, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Edison R PariseMaria L Ferraz
May 15, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Maartje A M BerendsJoost P H Drenth
Nov 6, 2007·Journal of Cellular and Molecular Medicine·O A GressnerA M Gressner
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Mar 11, 2015·The Journal of Infectious Diseases·Vincent Lo ReMary B Leonard
Dec 27, 2005·Comparative Hepatology·Thierry PoynardJanice Albrecht
Oct 17, 2007·BMC Gastroenterology·Thierry PoynardVictor de Ledinghen
Sep 11, 2010·BMC Gastroenterology·Mireen Friedrich-RustChristoph Sarrazin
Jul 6, 2014·BMC Gastroenterology·Marija ZeremskiAndrew H Talal
Oct 26, 2012·AJR. American Journal of Roentgenology·Richard H MarshallNancy K Davis
Sep 22, 2007·AJR. American Journal of Roentgenology·Bachir TaouliHillel Tobias
Jan 24, 2006·Seminars in Hematology·Craig M Kessler
Dec 2, 2006·La Revue de médecine interne·E Nguyen-Khac
Sep 15, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Olav A GressnerAxel M Gressner
May 30, 2009·Gastroenterología y hepatología·Joaquín PortillaEduardo Lissen
Mar 13, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Olav A Gressner, Chunfang Gao
Mar 16, 2017·World Journal of Hepatology·Maria Chiara ChindamoCristiane Alves Villela-Nogueira
Dec 20, 2017·Future Science OA·Krishna Sumanth NallagangulaMuninarayana Chandrappa
Aug 9, 2012·Biomarker Insights·Tianhui LiuFederica Genovese
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian MöllekenKai Stühler
Aug 14, 2018·Congenital Heart Disease·Jessica L SchachterGary A Abrams

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Methods Mentioned

BETA
biopsy
PCR
biopsies

Software Mentioned

GlycoCirrhoTest
FibroTest
METAVIR
NCSS
ActiTest

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