Overview of the Final MEIC Results: I. The In Vitro--In Vitro Evaluation

Toxicology in Vitro : an International Journal Published in Association with BIBRA
C Clemedson, B Ekwall

Abstract

In the MEIC study, the first 30 reference chemicals were tested in 82 in vitro toxicity assays while the last 20 chemicals were tested in 67 assays. To increase understanding of the performance of in vitro toxicity tests, these two subsets of results were compared by principal components analyses (PCA) combined with a "random probe" analysis of five key methodological factors, that is, the results from all pairs of methods which were similar in all other respects than the analysed factor were systematically compared by linear regression. This paper is an overview of these published comparisons, and also includes a new "random probe" analysis of another segment of the same MEIC results, namely tests of all 50 reference chemicals by 61 of the methods. A PCA indicated high general similarity (around 80%) of all the results from the 61 methods. According to the new "random probe" analysis, this similarity must depend on the high correlation of results from assays with different cell types (mean R(2) 0.81) and/or different viability endpoints (mean R(2) 0.85). Main factors contributing to the 20% dissimilarity of results were different exposure times and the use of phylogenetically distant test objects in the non-analogous ecotoxico...Continue Reading

References


❮ Previous
Next ❯

Citations

Jan 25, 2002·Journal of Applied Toxicology : JAT·Paul J Dierickx, Ellen M Scheers
Apr 14, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Willem G E J SchoonenEric Débiton
Apr 14, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Willem G E J SchoonenEric Débiton
Jun 16, 2001·Lancet·K Archibald
Nov 9, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P J Dierickx
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Paul J Dierickx
Oct 16, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Arturo Villegas-NavarroJosé L Reyes
Sep 13, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Saba SheikhR C Saxena
Jan 21, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Willem G E J SchoonenG Jean Horbach
Jul 14, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Agnieszka Kinsner-OvaskainenPilar Prieto
Jan 23, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Agnieszka Kinsner-OvaskainenPilar Prieto
Oct 12, 2005·Journal of Applied Toxicology : JAT·Fatma LestariAmanda J Hayes
Aug 8, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kenjiro KogaKazuhiro Shintani
Apr 3, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mounir BouhifdMaurice P Whelan
Nov 28, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Kinsner-OvaskainenA Kopp-Schneider
Aug 28, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P PrietoA Kopp-Schneider
Apr 2, 2019·Environmental Health Perspectives·Daniel P RussoHao Zhu
Dec 23, 2004·Alternatives to Laboratory Animals : ATLA·Hanna TähtiTarja Toimela
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monica ArgenzianoRoberta Cavalli
Jan 18, 2005·Alternatives to Laboratory Animals : ATLA·Helmut Segner
Jun 2, 2001·Alternatives to Laboratory Animals : ATLA·A NovilloA Castaño
Sep 10, 2005·Toxicology and Industrial Health·S BakandB Markovic
Sep 27, 2005·Alternatives to Laboratory Animals : ATLA·Michael Balls, Robert Combes
Sep 14, 2007·Alternatives to Laboratory Animals : ATLA·Carsten KneuerWalther Honscha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.