Sep 16, 1998

Overview of the preparation, use and biological studies on polyglycerol polyricinoleate (PGPR)

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
R WilsonD Howes

Abstract

The esterification of condensed castor oil fatty acids with polyglycerol gives a powerful water-in-oil emulsifier which is used by the food industry in tin-greasing emulsions and as an emulsifier with lecithin in chocolate couverture and block chocolate. A safety evaluation programme was undertaken in the late 1950s and early 1960s to determine whether this food emulsifier polyglycerol polyricinoleate (PGPR). (Quest International trade name ADMUL WOL) presented any health implications for consumers. This programme included acute toxicity tests, subacute rat and chicken toxicity studies, a rat chronic toxicity/multigeneration reproduction study, rodent metabolism, carcinogenicity testing in rat and mouse and a human clinical evaluation. PGPR was found to be 98% digested by rats and utilized as a source of energy superior to starch and nearly equivalent to groundnut oil. There was no interference with normal fat metabolism in rats or in the utilization of fat-soluble vitamins. Despite the intimate relationship with fat metabolism, no evidence was found of any adverse effects on such vital processes as growth, reproduction and maintenance of tissue homeostasis. PGPR was not carcinogenic in either 2-year rat or 80-week mouse feedin...Continue Reading

  • References6
  • Citations39

References

  • References6
  • Citations39

Citations

Mentioned in this Paper

Ricinelaidic acid
Hypertension, Essential, Susceptibility TO,6
Glycerin
Toxicity Tests
Chocolate
Ricinoleic Acids
ADMUL WOL
Drug Toxicity
Food Additives
Carcinogenicity Tests

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