Overview of the roles of Sox2 in stem cell and development

Biological Chemistry
Ruopeng Feng, Jinhua Wen

Abstract

Sox2 is well known for its functions in embryonic stem (ES) cell pluripotency, maintenance, and self-renewal, and it is an essential factor in generating inducible pluripotent stem (iPS) cells. It also plays an important role in development and adult tissue homeostasis of different tissues, especially the central nervous system. Increasing evidence has shown that aging is a stemness-related process in which Sox2 is also implicated as a key player, especially in the neural system. These distinct roles that Sox2 plays involve delicate regulatory networks consisting of other master transcription factors, microRNAs and signaling pathways. Additionally, the expression level of Sox2 can also be modulated transcriptionally, translationally or post-translationally. Here we will mainly review the roles of Sox2 in stem cell related development, homeostasis maintenance, aging processes, and the underlying molecular mechanisms involved.

References

Jun 1, 1997·Current Opinion in Genetics & Development·L H Pevny, R Lovell-Badge
Feb 26, 2000·Science·F H Gage
Jul 7, 2000·Molecular and Cellular Neurosciences·F J RubioA Martínez-Serrano
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Karen Z H Li, Ulman Lindenberger
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Sep 2, 2003·Neuron·Victoria GrahamLarysa Pevny
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander Y MaslovSteven C Pruitt
Mar 9, 2004·Neuron·Arturo Alvarez-Buylla, Daniel A Lim
Oct 1, 2004·Molecular and Cellular Biology·Shinya TanakaHisato Kondoh
Nov 2, 2004·Nature Cell Biology·Karl J L FernandesFreda D Miller
Nov 3, 2004·Molecular and Cellular Neurosciences·Suling ZhaoMeng Li
Dec 1, 2004·Aging Cell·Kimberly J BaileySteven C Pruitt
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nam LeJeffrey Milbrandt
Apr 23, 2005·Nature·Amy E KiernanKathryn S E Cheah
Mar 18, 2006·Human Molecular Genetics·Kathleen A WilliamsonDavid R FitzPatrick
May 3, 2006·Genes & Development·Olena V TaranovaLarysa H Pevny
Aug 26, 2006·The Journal of Clinical Investigation·Daniel KelbermanMehul T Dattani
Oct 4, 2006·Genes & Development·Tadashi OkuboBrigid L M Hogan
Nov 14, 2006·Biochemical and Biophysical Research Communications·Shu TsuruzoeMitsuyoshi Nakao
Mar 3, 2007·The European Journal of Neuroscience·Neal R MelvinRobert J Sutherland
Dec 29, 2007·The American Journal of Surgical Pathology·Ji Hoon PhiKyu-Chang Wang
Jan 4, 2008·Development·Maurizio CavallaroSilvia K Nicolis
Feb 21, 2008·Neuromolecular Medicine·Klaus Fabel, Gerd Kempermann
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Teddy FauquierIain C A F Robinson
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
May 2, 2008·Stem Cells and Development·Kara M Foshay, G Ian Gallicano
May 6, 2008·Neurobiology of Aging·Nada M-B Ben AbdallahHans-Peter Lipp
May 6, 2008·The Journal of Biological Chemistry·Yupeng ChenYongfeng Shang
Jul 8, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Katia R LeiteLuiz H Camara-Lopes
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alain DabdoubMatthew W Kelley
Jul 11, 2009·Stem Cells·Gretchen A BaltusShilpa Kadam
Aug 12, 2009·Cell Stem Cell·Dennis Van HoofJeroen Krijgsveld

❮ Previous
Next ❯

Citations

Jun 18, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E Christopher PartridgeEric M Mendenhall
Feb 19, 2017·Molecular Cell·Guillaume Gaullier, Karolin Luger
Jul 22, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rondell P GrahamAndrew L Folpe
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yuan YinYi Sun
Apr 15, 2020·Nature Communications·Zachariah E HolmesRobert T Batey
Oct 19, 2017·Molecular Medicine Reports·Yali YangLei Zhao
Sep 22, 2019·International Journal of Molecular Sciences·Sara MercurioSilvia K Nicolis
Jul 16, 2020·International Journal of Molecular Sciences·Thorsten SchaeferClaudia Lengerke
Sep 7, 2018·Frontiers in Pharmacology·Peng LiuLongzhong Liu
Aug 28, 2020·Frontiers in Physiology·Christian T MeiselThimios A Mitsiadis
Jun 12, 2016·Environmental Epigenetics·Carrie V BretonFrank Gilliland
Nov 22, 2019·Protein & Cell·Shizhen Zhang, Yi Sun
Nov 8, 2018·Stem Cells International·Hang LiangZengwu Shao
Dec 16, 2020·Investigative Ophthalmology & Visual Science·Yu-Ting XiaoXin-Yue Zhao
Dec 2, 2020·Molecular and Cellular Biology·Makoto HoriuchiMasayuki Yamamoto
Mar 16, 2021·Ophthalmic Genetics·Malena Daich VarelaBrian P Brooks
Aug 3, 2021·Regenerative Medicine·Chanzhen LiuXianlin Yi
Sep 9, 2021·Journal of Cosmetic Dermatology·Asmaa Gaber AbdouAzza Gaber Antar Farag

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved