Overview on rodent models of Alzheimer's disease

Current Protocols in Neuroscience
Jean-Cosme Dodart, Patrick May

Abstract

In Alzheimer's disease (AD), characteristic lesions develop in brain regions that subserve cognitive functions, ultimately leading to dementia. There are now several lesioned or transgenic small-animal models of the disease that model select aspects of cognitive deficits and/or recapitulate many, but not all, of the characteristic pathologic lesions observed in AD. This overview describes the most common approaches used to model AD in rodents, highlights their utility, and discusses some of their deficiencies.

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Citations

Oct 12, 2010·Journal of Neural Transmission·Brandon K HarveyMikko Airavaara
Oct 8, 2009·Human Molecular Genetics·Hsiuchen Chen, David C Chan
Nov 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ágnes KaszaLívia Fülöp
Sep 19, 2019·Current Protocols in Neuroscience·Ariana Myers, Paul McGonigle
Apr 24, 2015·Alzheimer's Research & Therapy·Diego Gomez-Nicola, Delphine Boche
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Adam O GhoweriOlivier Thibault

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