Overview on the Antihypertensive and Anti-Obesity Effects of Secondary Metabolites from Seaweeds

Marine Drugs
Ana M L Seca, Diana C G A Pinto

Abstract

Hypertension and obesity are two significant factors that contribute to the onset and exacerbation of a cascade of mechanisms including activation of the sympathetic and renin-angiotensin systems, oxidative stress, release of inflammatory mediators, increase of adipogenesis and thus promotion of systemic dysfunction that leads to clinical manifestations of cardiovascular diseases. Seaweeds, in addition to their use as food, are now unanimously acknowledged as an invaluable source of new natural products that may hold noteworthy leads for future drug discovery and development, including in the prevention and/or treatment of the cardiovascular risk factors. Several compounds including peptides, phlorotannins, polysaccharides, carotenoids, and sterols, isolated from brown, red and green macroalgae exhibit significant anti-hypertensive and anti-obesity properties. This review will provide a comprehensive overview of the recent advances on bioactive pure compounds isolated from different seaweed sources focusing on their potential use as drugs to treat or prevent hypertension and obesity. On the other hand, although it is obvious that macroalgae represent promising sources of antihypertensive and anti-obesity compounds, it is also c...Continue Reading

References

May 12, 2004·The Journal of Nutritional Biochemistry·Kunio SuetsunaJiun-Rong Chen
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Evan D Rosen, Ormond A MacDougald
Feb 2, 2008·Journal of the American College of Cardiology·Alan H Gradman, Rishi Kad
Oct 12, 2010·Journal of Agricultural and Food Chemistry·Huan Li, Rotimi E Aluko
May 11, 2011·Nutrition Research and Practice·W A J P WijesingheYou-Jin Jeon
Aug 23, 2011·The Medical Clinics of North America·Kerstyn C ZalesinPeter A McCullough
May 23, 2012·Marine Drugs·Nicolantonio D'OrazioGraziano Riccioni
Dec 29, 2012·Applied Biochemistry and Biotechnology·Hai-Lun HeChang-Bei Ma
Apr 5, 2014·Nutrition Reviews·Emma S BrownEmeir M McSorley
May 3, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·Gabriel B Habib, Sukhdeep S Basra
Jun 24, 2014·European Journal of Pharmacology·Suzanne A Nasser, Mahmoud M El-Mas
Aug 22, 2014·Journal of the Science of Food and Agriculture·Tae-Hyung KwonNyun-Ho Park
Sep 10, 2014·Planta medica·Paula KiuruJari Yli-Kauhaluoma
Apr 15, 2015·Marine Drugs·Maria Alessandra Gammone, Nicolantonio D'Orazio
Jul 5, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Kh MuradianV E Fraifeld
Sep 24, 2015·International Journal of Molecular Sciences·Maria Hayes, Brijesh K Tiwari
Feb 5, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Min-Cheol KangYou-Jin Jeon
Feb 13, 2016·Nutrition Research and Practice·Ji-Hyun OhYunkyoung Lee
Feb 27, 2016·Current Protein & Peptide Science·Thimmegowda Chandana, Yeldur P Venkatesh
Jan 1, 2015·Clinical Hypertension·Noah JarariLaxmi Teja Peela
Apr 1, 2011·Journal of Phycology·Pádraigín A Harnedy, Richard J FitzGerald
May 28, 2016·Circulation Research·Francisco B OrtegaSteven N Blair
Jul 1, 2016·Journal of Photochemistry and Photobiology. B, Biology·Kalu Kapuge Asanka SanjeewaYou-Jin Jeon
Dec 13, 2016·Marine Drugs·Chu Wan-Loy, Phang Siew-Moi
Dec 19, 2016·Carbohydrate Polymers·Duraikkannu Shanthana LakshmiC R K Reddy

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Citations

Oct 31, 2018·Marine Drugs·Djenisa H A RochaDiana C G A Pinto
Feb 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aroa Lopez-SantamarinaAlberto Cepeda
Oct 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mona M IsmailMostafa M El-Sheekh
Aug 14, 2020·Nutrients·Saioa Gómez-ZoritaMaría P Portillo
Jun 28, 2019·Nutrients·Lasse E SørensenSøren Gregersen
Apr 9, 2020·International Journal of Molecular Sciences·Oyindamola Vivian OjulariJu-Ock Nam
Oct 4, 2020·Marine Drugs·Raquel MateosHerminia Domínguez
Nov 7, 2019·GeroScience·Oleh LushchakAlexander Vaiserman
Nov 22, 2020·Marine Drugs·Lei CaoHyeung-Rak Kim
Apr 14, 2021·Journal of Agricultural and Food Chemistry·Yu-Hsuan HsiaoMin-Hsiung Pan
Jul 3, 2021·Marine Drugs·Emer ShannonMaria Hayes
Aug 19, 2020·Journal of Molecular Graphics & Modelling·Ahmed H Al SharieJosé L Medina-Franco

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