Overweight and Hyperinsulinemia Provide Individual Contributions to Compromises in Brachial Artery Distensibility in Healthy Adolescents and Young Adults: Brachial Distensibility in Children.

Journal of the American Society of Hypertension : JASH
Elaine M UrbinaLawrence M Dolan

Abstract

BACKGROUND: Brachial artery distensibility (BrachD) was measured in healthy children to identify associations with atherosclerotic risk factors. METHODS: 969 black and white subjects 13-22 years were classified as lean (L) or overweight (O) and hyperinsulinemic (H-I) or normoinsulinemic (N-I). BP and BrachD were obtained with a DynaPulse Pathway instrument. ANOVA was performed looking for group mean differences. Correlations between BrachD and risk variables were examined. Determinates of BrachD were determined by backward elimination regression stratified by BMI-Insulin group. RESULTS: Decreased BrachD correlated with male gender, O, higher BP, HR, fasting glucose and log of fasting insulin after adjusting for pulse pressure (PP). BrachD was greatest in L/N-I with progressive decreases seen in L/H-I, O/N-I, and O/H-I subjects. Regression modeling found PP and HR were major determinates of BrachD. Glucose was significant for subjects with N-I regardless of adiposity. Excluding BP, glucose remained important in N-I subjects. Gender was significant for all. HR retained significance only in O subjects regardless of insulin level. CONCLUSIONS: In healthy adolescents, hyperinsulinemia and obesity adversely affect brachial artery ...Continue Reading

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Oct 30, 2010·Indian Journal of Community Medicine : Official Publication of Indian Association of Preventive & Social Medicine·Wasim A ShaikhSk Singh
Sep 7, 2014·Current Treatment Options in Cardiovascular Medicine·Laurens P Koopman, Luc L Mertens
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Sep 27, 2018·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Nancy Anderson NiemczykEmma Barinas-Mitchell

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