Overweight and obesity at different times in life as risk factors for non-Hodgkin's lymphoma: the multiethnic cohort

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Gertraud MaskarinecLaurence N Kolonel

Abstract

Obesity may increase the risk for non-Hodgkin's lymphoma (NHL) through an inflammatory pathway. We explored the relation of NHL with body size at different times in life within the Multiethnic Cohort that includes African Americans, Caucasians, Japanese, Latinos, and Native Hawaiians. Participants were 45 to 75 years old at recruitment in 1993 to 1996. This analysis included 87,079 men and 105,972 women with 461 male and 378 female NHL cases. We used Cox regression to model NHL risk with age as the time metric while adjusting for age at baseline, ethnicity, education, alcohol intake, and age at first live birth. Body weight and body mass index at age 21 were stronger predictors of NHL risk than anthropometric characteristics at baseline. For men, being in the highest quartile of body mass index and body weight at age 21 conferred a nonsignificant 86% and 41% higher NHL risk, respectively, whereas there was no association at baseline. For women, the risk associated with the highest quartile of weight at age 21 was 1.6 (P(trend) = 0.04), whereas women in the highest quartile at baseline had a nonsignificant risk of 27%. Height was positively related to NHL in men and women. Despite the small numbers, there was some consistency fo...Continue Reading

Citations

Apr 10, 2013·Cancer Chemotherapy and Pharmacology·David S HydockReid Hayward
Nov 15, 2011·Journal of the American College of Nutrition·Da-Ming ChuHsing-Yi Chang
Jul 30, 2014·Cancer Causes & Control : CCC·Qi Jie Nicholas LeoGertraud Maskarinec
Oct 3, 2012·Advances in Hematology·Alexander J AmbinderChristopher R Flowers
Jun 25, 2013·American Journal of Epidemiology·Nancy Potischman, Martha S Linet
Oct 27, 2012·Leukemia & Lymphoma·Alpa V PatelSusan M Gapstur
May 16, 2009·International Journal of Cancer. Journal International Du Cancer·Eva ErberLaurence N Kolonel
Oct 13, 2009·International Journal of Cancer. Journal International Du Cancer·Junya KandaHideo Tanaka
Feb 19, 2016·International Journal of Cancer. Journal International Du Cancer·TienYu Owen YangUNKNOWN Million Women Study Collaborators
Jul 12, 2012·The Korean Journal of Hematology·Jooryung Huh
Jan 18, 2017·Nutrition and Cancer·Tian-Jie HanHong-Zhi Xu
Feb 13, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L AbarT Norat
Jan 8, 2019·International Journal of Cancer. Journal International Du Cancer·Theodora PsaltopoulouMeletios A Dimopoulos
Sep 24, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Kai XueJia He
Aug 28, 2020·Cancer Causes & Control : CCC·Michael K OdutolaClaire M Vajdic
Jul 27, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K HidayatB-M Shi
Jun 28, 2013·Cancer Prevention Research·Kimberly A BertrandBrenda M Birmann
May 27, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Junya KandaUNKNOWN Japan Public Health Center-based Prospective Study Group
Sep 21, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yukiko MorimotoGertraud Maskarinec
May 13, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eleanor KaneEve Roman
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L AbarT Norat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.