Overweight and obesity during adolescence increases the risk of renal cell carcinoma

International Journal of Cancer. Journal International Du Cancer
Anna LandbergKatja Fall

Abstract

While overweight among adults has been linked with renal cell carcinoma (RCC) risk, little is known about the potential influence of overweight and obesity during adolescence. To ascertain if adolescent body mass index is associated with subsequent risk of RCC, we identified a cohort of 238,788 Swedish men who underwent mandatory military conscription assessment between 1969 and 1976 at a mean age of 18.5 years. At the time of conscription assessment, physical and psychological tests were performed including measurements of height and weight. Participants were followed through linkage to the Swedish Cancer Registry to identify incident diagnoses of RCC. The association between body mass index (BMI, kg/m2 ) at conscription assessment and subsequent RCC was evaluated using multivariable Cox regression. During a follow-up of up to 37 years, 266 men were diagnosed with RCC. We observed a trend for higher RCC risk with increasing BMI during adolescence, where one-unit increase in BMI conferred a 6% increased risk of RCC (95% CI 1.01-1.10). compared to normal weight men (BMI 18.5- < 25), men with overweight (BMI 25- < 30) or obesity (BMI ≥30) had hazard ratios for RCC of 1.76 (95% CI 1.16-2.67) and 2.87 (95% CI 1.26-6.25), respective...Continue Reading

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Citations

Apr 16, 2019·Expert Review of Molecular Diagnostics·Giuseppe LucarelliMichele Battaglia
Sep 13, 2019·Diabetologia·Jessica L HardingGiuseppina Imperatore
Mar 22, 2020·International Journal of Environmental Research and Public Health·Yunping ZhouDongfeng Zhang
Sep 10, 2020·International Journal of Cancer. Journal International Du Cancer·Kayo NakataUNKNOWN IICC-3 Contributors
Nov 25, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Sonali MalhotraVibha Singhal
Apr 22, 2021·Expert Review of Endocrinology & Metabolism·Sonali MalhotraFatima Cody Stanford
May 28, 2021·Expert Opinion on Biological Therapy·Carlo Di BonaJens Bedke
May 23, 2021·Journal of the National Cancer Institute·Zhe FangEdward L Giovannucci

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