Overweight and underweight are risk factors for vertebral fractures in patients with type 2 diabetes mellitus

Journal of Bone and Mineral Metabolism
Ippei KanazawaToshitsugu Sugimoto

Abstract

The aim of this cross-sectional study was to examine the association between body mass index (BMI) and the prevalence of vertebral fracture (VF) in Japanese patients with type 2 diabetes (T2DM). A total of 798 patients with T2DM were enrolled. VF was determined semi-quantitatively using lateral X-ray films. The association between BMI quartiles (Q1: ≤ 21.2 kg/m2, Q2: 21.3-23.4 kg/m2, Q3: 23.5-25.8 kg/m2, Q4: 25.9≤ kg/m2) and the presence of VF was examined. Multiple logistic regression analyses adjusted for age, sex, diabetes duration, hemoglobin A1c (HbA1c), estimated glomerular filtration rate, and albumin showed that Q1, Q3, and Q4 were significantly associated with an increased VF risk compared to Q2, which served as a reference [Q1; odds ratio (OR) = 1.91, 95% confidence interval (CI) 1.24-2.95, p = 0.004, Q3; OR = 1.65, 95% CI 1.07-2.55, p = 0.023, and Q4; OR = 2.18, 95% CI 1.39-3.41, p < 0.001]. Moreover, these associations remained significant after additional adjustment for femoral neck T-score, a bone resorption marker, urinary N-terminal cross-linked telopeptide of type-I collagen, and use of insulin and thiazolidinedione. Our study shows for the first time that both overweight and underweight were associated with th...Continue Reading

References

Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H K GenantS R Cummings
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P RavnC Christiansen
Nov 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A CauleyD Black
Feb 7, 2001·The American Journal of Clinical Nutrition·T A RicciS A Shapses
May 28, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T YamaguchiK Chihara
Aug 3, 2002·European Journal of Endocrinology·Miyao MatsubaraShinji Katayose
Feb 11, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D K RoyUNKNOWN European Prospective Osteoporosis Study (EPOS)
Dec 24, 2004·Journal of Bone and Mineral Metabolism·Toru YamaguchiKazuo Chihara
Jun 2, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C De LaetA Tenenhouse
Jun 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A H HolmbergK Akesson
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiang-Hang LuoEr-Yuan Liao
Oct 28, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Vestergaard
Mar 17, 2007·Diabetes Care·Seok Won ParkUNKNOWN Health, Aging, and Body Composition Study
Jun 19, 2007·American Journal of Epidemiology·Mohsen JanghorbaniFrank B Hu
Dec 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masahiro YamamotoToshitsugu Sugimoto
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·Ippei KanazawaToshitsugu Sugimoto
Jul 7, 2009·Journal of Bone and Mineral Metabolism·Matteo PirroElmo Mannarino
Jun 10, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I KanazawaT Sugimoto
Aug 19, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L L LaslettG Jones
Aug 11, 2012·Current Medicinal Chemistry·I Kanazawa
Jan 26, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Carrie M NielsonEric S Orwoll
Jun 19, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Helena JohanssonM Carola Zillikens
Jul 23, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Juliet E CompstonUNKNOWN GLOW Investigators
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Doosup ShinSang Min Park
Mar 20, 2014·The Journal of Clinical Investigation·Jianwen WeiGerard Karsenty
May 27, 2014·Expert Opinion on Drug Discovery·Morena ScoteceOreste Gualillo
May 28, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mei Y ChanTuan V Nguyen
Nov 26, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N YoshimuraT Akune
Nov 4, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A D KazeJ M Paik

❮ Previous
Next ❯

Citations

Mar 26, 2019·Journal of Cellular and Molecular Medicine·Na WangPeng Xue
Jan 8, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z ZhangX-H Zhou
Jan 13, 2021·Current Osteoporosis Reports·Fjorda KoromaniLing Oei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.