Overweight is a risk factor for both erosive and non-erosive reflux disease

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Edoardo SavarinoVincenzo Savarino

Abstract

Studies have reported that the association between overweight and erosive oesophagitis is very strong, whilst seeming less consistent with non-erosive reflux disease. We have hypothesized that this difference may be due to the heterogeneity of endoscopy-negative population. We studied 81 patients with erosive oesophagitis, 48 controls and 295 endoscopy-negative patients classified by impedance-pH-testing as: (1) pH-POS (abnormal acid exposure); (2) hypersensitive oesophagus (normal acid exposure/SAP+); (3) functional heartburn (normal acid exposure/SAP-). Body mass index was also calculated. Mean body mass index was significantly higher (p<0.05) in erosive oesophagitis than in endoscopy-negative patients as a whole and controls [27 (18-40) vs. 25 (16-48) vs. 23 (16-34)]. However, the separation of endoscopy-negative patients showed that mean body mass index was higher (p<0.05) in those with increased acid exposure time [26 (18-45)] than in hypersensitive oesophagus [24 (16-48)]. The former subgroup was similar to erosive oesophagitis, whilst the latter one to both functional heartburn [23 (16-34)] and controls (p=ns). Increased body mass index represented a risk factor for erosive oesophagitis (odds ratio 1.4; 95% confidence in...Continue Reading

References

Jul 1, 1991·Journal of Internal Medicine·L I Andersen, G Jensen
Oct 1, 1986·Gastroenterology·P J KahrilasA Reece
Jul 20, 1994·JAMA : the Journal of the American Medical Association·R J KuczmarskiC L Johnson
Jun 22, 1999·Annals of Internal Medicine·J LagergrenO Nyrén
Aug 13, 1999·The American Journal of Gastroenterology·A J Cameron
Aug 19, 1999·Journal of Gastroenterology·N FurukawaK Fujimoto
Mar 14, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A J Smout
Jun 20, 2001·Gut·S J Spechler, D O Castell
Jul 20, 2002·Scandinavian Journal of Gastroenterology·M NilssonJ Lagergren
Mar 8, 2003·Alimentary Pharmacology & Therapeutics·S D MartinezR Fass
Aug 28, 2004·The American Journal of Gastroenterology·Joachim LabenzPeter Malfertheiner
Jun 3, 2005·The American Journal of Gastroenterology·Hashem B El-SeragLinda Rabeneck
Aug 3, 2005·Annals of Internal Medicine·Howard HampelHashem B El-Serag
Feb 17, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P ZentilinV Savarino
Mar 15, 2006·Gastroenterology·John E PandolfinoPeter J Kahrilas
Apr 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M FrazzoniV Savarino
May 9, 2006·Gastroenterology·Jean Paul GalmicheAndre J P M Smout
Sep 6, 2006·The American Journal of Gastroenterology·Douglas A Corley, Ai Kubo
Feb 28, 2007·Gastroenterology·Justin Che-Yuen WuJoseph Jao-Yiu Sung
May 15, 2007·Gastroenterology·Cynthia L OgdenKatherine M Flegal
Jul 17, 2007·Gastroenterology·Douglas A CorleyPatricia A Buffler
Sep 1, 2007·Current Treatment Options in Gastroenterology·Tomás Navarro-Rodriguez, Ronnie Fass
Sep 11, 2007·Digestive Diseases·Vincenzo SavarinoPietro Dulbecco
Sep 12, 2007·Journal of Gastroenterology and Hepatology·Mun Su KangByung Ik Kim
Feb 13, 2008·Gut·Hashem El-Serag
Feb 22, 2008·The American Journal of Gastroenterology·Paul Moayyedi
May 31, 2008·The American Journal of Gastroenterology·John E Pandolfino
Sep 9, 2008·The American Journal of Gastroenterology·Edoardo SavarinoVincenzo Savarino
Nov 4, 2008·Journal of Clinical Gastroenterology·Hang Lak LeeSoon Young Song
Apr 1, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·L A HealyJ V Reynolds
Jun 11, 2010·Journal of Neurogastroenterology and Motility·Tiberiu Hershcovici, Ronnie Fass
Jun 11, 2010·Journal of Neurogastroenterology and Motility·Su Youn Nam
Mar 8, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo SavarinoVincenzo Savarino

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Citations

Aug 10, 2013·Clinical Oral Investigations·Andrea OttonelloEdoardo Savarino
May 3, 2014·Surgical Endoscopy·Karl Hermann FuchsUNKNOWN European Association of Endoscopic Surgery (EAES)
Aug 2, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo SavarinoChiara de Cassan
Nov 1, 2011·Journal of Gastroenterology·Edoardo SavarinoVincenzo Savarino
Jun 28, 2013·Expert Opinion on Drug Metabolism & Toxicology·Nicola de BortoliEdoardo Savarino
Sep 12, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca MieleAntonio Grieco
Oct 15, 2013·Annals of the New York Academy of Sciences·G Richard LockeFouad Moawad
Dec 18, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N de BortoliS Marchi
Jun 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nicola De BortoliEdoardo V Savarino
Jun 30, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo Savarino, Vincenzo Villanacci
Sep 7, 2016·Expert Opinion on Pharmacotherapy·Edoardo SavarinoVincenzo Savarino
Sep 16, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Serhat BorRukiye Vardar
Sep 21, 2016·The American Journal of Gastroenterology·Nicola de BortoliSantino Marchi
Oct 28, 2016·Annals of the New York Academy of Sciences·Edoardo SavarinoEllen Stein
Oct 28, 2016·Annals of the New York Academy of Sciences·Nicola de BortoliEdoardo Savarino
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Nicola de BortoliEdoardo Vincenzo Savarino
Nov 2, 2013·Therapeutic Advances in Chronic Disease·Irene MartinucciSantino Marchi
May 31, 2018·Current Opinion in Gastroenterology·Edoardo SavarinoVincenzo Savarino
Jul 20, 2019·Expert Review of Gastroenterology & Hepatology·Matteo GhisaEdoardo Savarino
Jan 28, 2014·Journal of Neurogastroenterology and Motility·Edoardo SavarinoVincenzo Savarino
Nov 19, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Edoardo SavarinoVincenzo Savarino
Jul 30, 2017·Expert Opinion on Pharmacotherapy·Edoardo SavarinoVincenzo Savarino
Nov 20, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E SavarinoV Savarino
May 26, 2018·Digestive Diseases and Sciences·Mariko HojoSumio Watanabe
Sep 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N de BortoliS Marchi
May 8, 2019·Obesity Surgery·Salvatore ToloneLudovico Docimo
May 7, 2015·World Journal of Gastroenterology : WJG·Yasuhiro TamuraKunio Kasugai
Jun 25, 2020·Digestive Diseases and Sciences·Cesare TosettiUNKNOWN Study Group for the Evaluation of GERD Triggering Foods
Nov 28, 2020·Obesity Surgery·Flavia Carvalho SilveiraBradley F Schwack
Apr 29, 2021·Drug Design, Development and Therapy·Vincenzo SavarinoEdoardo Savarino

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