PMID: 7546619Jun 1, 1995Paper

Oviductal function is critical for very early human life

Annals of Medicine
M O Pulkkinen

Abstract

For normal fertilization, the ovum must be picked up from the ovarian surface or from the abdominal cavity into the ampulla. The rapid transport of gametes includes a complex reorganization of the oviductal smooth muscle electrical activity that precedes the mechanical activity. The 3-day stay at the ampulla-isthmic junction requires both signals from the ovum to the oviduct and vice versa, supporting the ovum and regulating its to-and-fro movements. Oviductal fluid, a principal factor in tubal function, coats the newly fertilized egg, activates transcription and gives a signal for sperm fertility potential. Early blocks to embryo development in in vitro conditions, as compared to in vivo success, means that critical developments during the first cell cycles of embryonic life in the oviduct are actively regulated by oviductal embryotrophic factors. These have been used clinically in co-culture systems. Lytic factors are weak in human and other primates, predisposing to high incidence of tubal pregnancies, with considerable impact on medical practice. Diverse oviductal factors affect the incidence, infection being the most significant. Optimal oviductal function is necessary to provide a proper environment for early human life.

References

Jan 1, 1991·Annals of the New York Academy of Sciences·R Sayegh, L Mastroianni
Jun 1, 1989·Biology of Reproduction·S A HalbertS E Szal
Mar 1, 1987·Clinical Obstetrics and Gynecology·J B Russell
Mar 1, 1987·Clinical Obstetrics and Gynecology·M O Pulkkinen, A Talo
Mar 1, 1987·Clinical Obstetrics and Gynecology·G Lavy, A H DeCherney

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Citations

Jul 1, 1997·Molecular Reproduction and Development·S HuangP Talbot
Jan 7, 1998·Fertility and Sterility·M Rantala, J Mäkinen
Mar 19, 2003·Reproductive Toxicology·Karen RivelesP Talbot
May 14, 2004·Reproductive Biology and Endocrinology : RB&E·Karen RivelesPrue Talbot
Sep 30, 2005·Reproductive Biology and Endocrinology : RB&E·Prue Talbot, Karen Riveles
Apr 6, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Juan Manuel Corpa
Jun 11, 2014·Nature Communications·Nannan NingJingxin Li
Oct 25, 2013·Zygote : the Biology of Gametes and Early Embryos·Juan M Teijeiro, Patricia E Marini
Jul 20, 2017·Molecular Reproduction and Development·Kailun Hu, Yang Yu
Jan 20, 2018·Wiley Interdisciplinary Reviews. Developmental Biology·Zahida Yesmin RolyCraig A Smith
Apr 10, 2007·Annals of the New York Academy of Sciences·I ZervomanolakisL Wildt

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