PMID: 2492399Jan 1, 1989Paper

Ovine arthrogryposis and central nervous system malformations associated with in utero Cache Valley virus infection: spontaneous disease

Veterinary Pathology
J F EdwardsE W Collisson

Abstract

Gross appearance and histologic lesions seen in 15 newborn lambs in an outbreak of congenital arthrogryposis with hydrocephalus or hydranencephaly (CAH) in Texas are described. Severe arthrogryposis with skeletal muscle hypoplasia was seen in limbs of affected lambs. Spinal column deformities were also present. Multiple central nervous system (CNS) malformations were present in CAH lambs including micrencephaly, cerebellar hypoplasia, micromelia, hydrocephalus, hydranencephaly, and porencephaly. Histologic lesions consisted primarily of areas of necrosis and loss of the paraventricular neuropil and motor neurons in the CNS and a resolving myositis with poorly developed myotubular myocytes in skeletal muscle. Seroepidemiologic studies on the flock and serologic data from heart blood taken from the stillborn affected lambs indicated that the outbreak was due to in utero infection with Cache Valley Virus.

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Citations

Feb 1, 1990·Veterinary Microbiology·S I ChungE W Collisson
Feb 20, 1997·The New England Journal of Medicine·D J SextonT G Ksiazek
Nov 17, 2005·Journal of Neurovirology·Samantha S Soldan, Francisco González-Scarano
Mar 8, 2013·Journal of Virology·Aline Rodrigues HoffmannJohn Francis Edwards
Aug 14, 2013·BMC Veterinary Research·Valentín PérezJuan José Arranz
Apr 7, 2012·Journal of Toxicologic Pathology·Chika HirowatariHiroshi Maeda
Aug 8, 2013·Journal of the American Mosquito Control Association·G D JohnsonR W Kott
Oct 10, 2012·The American Journal of Tropical Medicine and Hygiene·Bradley J BlitvichMaria A Loroño-Pino
Mar 19, 2016·Vector Borne and Zoonotic Diseases·Pedro F C Vasconcelos, Charles H Calisher
Nov 22, 2002·The Veterinary Clinics of North America. Food Animal Practice·Peter D Kirkland
Oct 5, 2006·Journal of Medical Entomology·Kiet A NgoLaura D Kramer
Jan 7, 2017·PLoS Neglected Tropical Diseases·Isabelle DietrichEsther Schnettler
May 13, 2015·The American Journal of Tropical Medicine and Hygiene·Philip M ArmstrongJohn F Anderson
Dec 13, 2005·Anais Da Academia Brasileira De Ciências·Bruno B AndradeManoel Barral-Netto
Jan 1, 1990·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D L Montgomery, W C Gilmore
Apr 1, 1995·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·G A BradleyM W Riggs
Jul 1, 1993·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·S P SchmidtR K Myers
Sep 13, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ana Lucia SchildFranklin Riet-Correa
Jul 20, 2018·Journal of Virology·Giantonella PuggioniCiriaco Ligios
Jul 26, 2000·The Veterinary Record·M L DohertyM P Boland
Apr 12, 2020·Parasites & Vectors·Kevin K ChanSally L Paulson
Jan 1, 2014·Veterinary Record Open·Gregory D JohnsonBradley J Blitvich
May 24, 2003·Journal of the American Veterinary Medical Association·John F EdwardsElizabeth C Pannill
Oct 29, 2020·PLoS Neglected Tropical Diseases·Arthur Wouter Dante Edridge, Lia van der Hoek
Aug 7, 2021·Emerging Microbes & Infections·Krisangel LópezAlbert J Auguste

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