Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium.

Endocrinology
T E Spencer, F W Bazer

Abstract

Tau interferons (IFNtau) are a unique subclass of the omega interferons that are transiently produced by the trophectoderm of the conceptus (embryo and associated membranes) during early pregnancy in ruminants. IFNtau acts as an antiestrogen on the endometrium to suppress increases in estrogen receptor (ER) and oxytocin receptor (OTR) gene expression which prevents pulsatile production of prostaglandin F2alpha and regression of the corpus luteum or luteolysis. In this study, steady-state levels of ER mRNA and transcription rates of the ER and OTR genes were two-fold lower in the endometrium of pregnant as compared to cyclic ewes on day 15. Levels of ER mRNA and ER and OTR gene transcription were also two-fold lower in the endometrium of day 15 cyclic ewes receiving intrauterine injections of recombinant ovine IFNtau from day 11 to day 14 compared to control ewes. Results suggest that the antiluteolytic action of IFNtau is to suppress transcription of the ER gene by a negative-acting transcriptional mechanism which prevents estrogen-induced increases in OTR gene expression in the endometrium. The novel antiestrogenic effects of IFNtau, combined with its Type I IFN characteristics and low cytotoxicity, suggest that this trophobla...Continue Reading

Citations

Jan 3, 2014·TheScientificWorldJournal·Ashok K BalharaInderjeet Singh
Jul 9, 2004·Reproductive Biology and Endocrinology : RB&E·Thomas E Spencer, Fuller W Bazer
Mar 22, 2013·PLoS Computational Biology·Winston A HaynesEugene Kolker
Sep 6, 2003·Reproductive Biology and Endocrinology : RB&E·Seokwoon KimFuller W Bazer
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Feb 26, 2010·Journal of Virology·Frederick ArnaudMassimo Palmarini
Nov 12, 2010·Domestic Animal Endocrinology·G SongF W Bazer
Aug 1, 1998·Biology of Reproduction·K L StaggsT R Hansen
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Jul 27, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tomasz MajAnna Che Mo Ska-Soyta
Feb 20, 2004·Biology of Reproduction·Thomas E SpencerFuller W Bazer
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Nov 22, 2011·Molecular Reproduction and Development·Hanako BaiKazuhiko Imakawa

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