Ovine pericardium: a new material for duraplasty

Journal of Neurosurgery
J ParízekP Suba

Abstract

The authors report on their 2 1/2-year clinical experience using a dural substitute, ovine pericardium, stabilized with 0.3% glutaraldehyde, flat freeze-dried, and sterilized with gamma-irradiation. Packaging of the ovine pericardium in double-plastic transparent bags allows simple storage in operating rooms and the opportunity for the surgeon to choose an ideal graft according to its shape, size, and plasticity. The ovine pericardia were examined histologically and by transmission and scanning electron microscopy in their native, freeze-dried, and irradiated forms. The final product is composed solely of pericardium fibrosum interwoven with artificially formed extracellular microcavities that serve as natural pores for the ingrowth of host tissue. The surfaces of the grafts appear smooth on the inner and rough on the outer sides. Sixteen grafts were examined macroscopically at autopsy and four of these were also examined histologically to illustrate their successful healing with no adhesion to the underlying brain. As a new dural substitute, ovine pericardium proved to be superior to bovine and allogeneic pericardia because of its workability, flexibility, and reduced thickness. In a study of 120 grafts, all but one healed wit...Continue Reading

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Citations

Aug 24, 1999·Transplantation Proceedings·R PisaniS L Gentile
Feb 10, 1999·Surgical Neurology·M A CobbF A Boop
Jun 19, 2002·Biomaterials·D DufraneY J Schneider
Jul 26, 2002·Clinical Neurology and Neurosurgery·A BaharuddinJ Abdullah
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Jul 2, 2016·Asian Journal of Neurosurgery·Roberto CentonzeLetterio Morabito
Nov 28, 2012·Advanced Healthcare Materials·Wenying LiuYounan Xia
Sep 30, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Elizabeth A Nunamaker, Daryl R Kipke
Feb 23, 2020·Biotechnology Journal·Ekaterina A GrebenikPeter S Timashev
Mar 18, 2006·Neurosurgery·Shunsuke TerasakaTakanori Uchida
Jun 2, 2000·Neurosurgery·R FilippiO Kempski
May 28, 2019·The International Journal of Artificial Organs·Alexandru MogaldeaAndres Hilfiker

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