Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription.

The Journal of Cell Biology
Mahalakshmi NairXing Dai

Abstract

Transcriptional control plays a key role in regulating epidermal proliferation and differentiation. Although ample information has been obtained on how epidermal homeostasis is controlled in adult skin, less is known about the control of proliferation/differentiation of epidermal stem/progenitor cells in the developing embryo. Ovol1, encoding a zinc finger protein homologous to Drosophila melanogaster Ovo, is expressed in embryonic epidermal progenitor cells that are transiting from proliferation to terminal differentiation. In this study, we demonstrate a function for Ovol1 in interfollicular epidermal development. In its absence, developing epidermis fails to properly restrict the proliferative potential of progenitor cells, and cultured keratinocytes fail to efficiently undergo growth arrest in response to extrinsic growth-inhibitory signals. We present molecular evidence that c-myc expression is up-regulated in Ovol1-deficient suprabasal cells and that Ovol1 represses c-myc transcription by directly binding to its promoter. Collectively, our findings indicate that Ovol1 is required for proliferation exit of committed epidermal progenitor cells and identify c-myc as an Ovol1 target.

References

Mar 1, 1978·European Journal of Biochemistry·L R GurleyR A Tobey
Sep 1, 1987·Genes & Development·N HayD Levens
Nov 1, 1987·Genes & Development·B OliverA P Mahowald
Jun 1, 1993·Molecular and Cellular Biology·V C Bond, B Wold
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W S PearD Baltimore
Apr 9, 1999·Science·K TakedaS Akira
May 3, 2000·The Journal of Investigative Dermatology·R CaldelariE Müller
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·J Massagué
May 31, 2001·Nature Genetics·R L WaikelD R Roop
Apr 25, 2002·Nature Reviews. Genetics·Elaine Fuchs, Srikala Raghavan
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Baoan LiXing Dai
May 8, 2002·Nature Reviews. Molecular Cell Biology·M Angela Nieto
Jun 7, 2002·Genes & Development·Kevin M McGowanPierre A Coulombe
Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Stacy MazzalupoPierre A Coulombe
Jul 15, 2003·Molecular Biology of the Cell·David OlmedaAmparo Cano
Jan 20, 2004·Genes & Development·Maranke I KosterDennis R Roop
Feb 6, 2004·Journal of Dermatological Science·Maranke I Koster, Dennis R Roop
Feb 18, 2004·Molecular and Cellular Biology·Daniel J MurphyGerard I Evan
Sep 24, 2004·Current Opinion in Genetics & Development·Xing Dai, Julia A Segre
Feb 22, 2005·Nature Cell Biology·Azadeh ArabiAnthony P H Wright
Mar 22, 2005·Biochimica Et Biophysica Acta·Jennifer A Sanders, Philip A Gruppuso
Oct 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qiutang LiInder M Verma
Jan 21, 2006·Developmental Biology·Douglas R MackayXing Dai

❮ Previous
Next ❯

Citations

Nov 22, 2011·Nature Cell Biology·Elisabete M NascimentoMichaela Frye
Dec 27, 2011·Nature Genetics·Lavinia PaternosterUNKNOWN EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium
Feb 23, 2008·Nature Reviews. Cancer·Fiona M WattSalvador Aznar Benitah
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pascal DescarguesMichael Karin
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Barbara MarinariAntonio Costanzo
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Elisabetta BottiAntonio Costanzo
Dec 14, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shuang LiuYinling Hu
Nov 22, 2008·Cold Spring Harbor Symposia on Quantitative Biology·E Fuchs, J A Nowak
May 11, 2007·Annual Review of Cell and Developmental Biology·Maranke I Koster, Dennis R Roop
Sep 4, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Youssef A Kousa, Brian C Schutte
Jan 23, 2008·The Journal of Cell Biology·Elaine Fuchs
Feb 14, 2016·The American Journal of Pathology·Takamichi ItoMasutaka Furue
Oct 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Stephen J RenaudMichael J Soares
Aug 8, 2013·The Journal of Investigative Dermatology·Yifang ChenGeorge L Sen
Sep 27, 2008·The EMBO Journal·Pascal DescarguesMichael Karin
Sep 4, 2010·Experimental Dermatology·Gabrielle S Le ProvostPascal Sommer
Mar 19, 2014·The Journal of Dermatology·Mayumi Tamari, Tomomitsu Hirota
Aug 22, 2006·Current Opinion in Genetics & Development·Fiona M WattVioleta Silva-Vargas
Sep 20, 2015·Clinical Reviews in Allergy & Immunology·Yunsheng LiangQianjin Lu
Aug 2, 2011·Developmental Biology·Sheila M BellJeffrey A Whitsett
Mar 21, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Christopher J RickettsEamonn R Maher
Jul 11, 2008·Developmental Biology·Mahalakshmi NairXing Dai
Dec 10, 2016·Birth Defects Research·Youssef A KousaBrian C Schutte
Mar 25, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takamichi ItoMasutaka Furue
May 2, 2017·The Journal of Investigative Dermatology·Briana LeeXing Dai
May 28, 2013·International Journal of Molecular Sciences·Shuang LiuEnkui Duan
Jul 3, 2013·International Journal of Molecular Sciences·Michael CangkramaCharbel Darido
Jun 4, 2013·International Journal of Molecular Sciences·Jin LiXiaofeng Jia
Jun 14, 2014·Nature Communications·Alexander A NavariniJonathan N Barker
Jun 9, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·R LichtenbergerA A Navarini
Jul 24, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Masutaka FurueGaku Tsuji
Aug 16, 2013·Current Opinion in Allergy and Clinical Immunology·Ingo MarenholzYoung-Ae Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
transfection
immunoprecipitation
ChIP
Assay

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.