Abstract
The ovarian surface epithelium (OSE) has a prominent role in ovarian cancer in women, but no studies have been conducted to evaluate its role in normal ovarian function. Data from other species suggest the OSE is needed for ovulation. We have tested whether the OSE is needed for follicle rupture, a necessary step in ovulation, using the nonhuman primate, rhesus macaque. The OSE was removed in two different short-term protocols spanning a single periovulatory interval--one protocol used a cytology brush to remove the OSE only from the follicle apex, and one used mild detergent to remove the entire OSE--and in one long-term protocol spanning 6 wk (two periovulatory intervals) that removed the entire OSE with detergent. Serum levels of estrogen and progesterone (E and P) were monitored, and sectioned ovaries were examined for evidence of successful OSE removal and follicle rupture. In the short-term protocols, removal of the OSE over the follicle apex did not prevent follicle rupture (n = 4 ovaries), but removal of the entire OSE using detergent did in four of six cases. In the long-term protocol, when ovaries were collected after the second periovulatory interval, all the ovaries (n = 5) showed evidence of follicle rupture. In al...Continue Reading
References
May 15, 1975·Experientia·L Bjersing, S Cajander
Nov 1, 1990·Molecular Reproduction and Development·D P WolfR L Stouffer
Jun 1, 1990·Scandinavian Journal of Dental Research·H S Bleeg
Oct 1, 1985·Biology of Reproduction·H O OsterholzerS V Nicosia
Mar 1, 1974·Biology of Reproduction·L L Espey
Sep 1, 1981·Journal of Reproduction and Fertility·T Mori, T A Uchida
Mar 1, 1994·Human Reproduction·W R GillettP F McComb
Jun 1, 1997·Animal Reproduction Science·D C Colgin, W J Murdoch
May 16, 1998·The Journal of Endocrinology·W J Murdoch
Apr 30, 1999·Human Reproduction·C L ChaffinR L Stouffer
Dec 8, 2000·Steroids·R L RobkerJ S Richards
May 22, 2002·Endocrinology·Jay W WrightKarin D Rodland
Aug 30, 2002·Molecular Human Reproduction·K A YoungR L Stouffer
May 8, 2003·Journal of Medical Primatology·Charleen M MooreRobert G Best
Oct 31, 2003·Human Reproduction·Kelly A YoungRichard L Stouffer
Jan 8, 2004·Endocrine·Diane M Duffy, Richard L Stouffer
Jun 1, 2004·Experimental Biology and Medicine·William J Murdoch, James F Martinchick
Jul 2, 2004·Biology of Reproduction·O L Tan, J S Fleming
Oct 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·O GubbayS G Hillier
Mar 29, 2005·Contraception·Fuhua XuRichard L Stouffer
Dec 13, 2005·Experimental Biology and Medicine·Julie M WuMary Ann Ottinger
Jan 3, 2006·Journal of Genetic Counseling·Jessica A RayMolly Brewer
Oct 31, 2006·Molecular Human Reproduction·A-K LindM Brännström
Nov 15, 2007·Human Reproduction·Jay W WrightRichard L Stouffer
Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Elizabeth M HosfieldCharles J Zaloudek
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·G H SandmannT Tischer
Nov 22, 2008·Lancet·Paolo MacchiariniMartin A Birchall
Jan 15, 2009·Journal of the National Cancer Institute·Timothy R RebbeckSusan M Domchek
Citations
Mar 23, 2011·Human Reproduction·Jay W WrightRichard L Stouffer
Mar 23, 2011·Human Reproduction·Jay W WrightRichard L Stouffer
Oct 22, 2011·Human Reproduction·J DietlE Geissinger
Dec 18, 2010·Molecular and Cellular Endocrinology·Katharina Spanel-Borowski
Nov 27, 2018·Carcinogenesis·Matthew DeanJoanna E Burdette
Sep 10, 2015·Nature Reviews. Molecular Cell Biology·Annie Ng, Nick Barker
Jul 28, 2019·Biology of Reproduction·Lauren E CarterBarbara C Vanderhyden
Jun 28, 2019·Cancers·Matthew DeanJoanna E Burdette
Mar 7, 2021·International Journal of Molecular Sciences·Dinesh BhartiGyu-Jin Rho