OX40 (CD134) blockade inhibits the co-stimulatory cascade and promotes heart allograft survival

Transplantation
Allison J CurryEleanor M Bolton

Abstract

CD134 (OX40) is a member of the tumor necrosis factor receptor superfamily that is expressed as a late event in T-cell activation and contributes to the generation of immunologic memory. CD134 blockade effectively ameliorates inflammation in models of autoimmune disease, but its role in transplantation has been less well studied. The authors used an OX40-immunoglobulin (Ig) fusion protein to examine the contribution of this co-stimulatory molecule to the in vitro alloimmune response and studied the ability of CD134 blockade to prevent cardiac allograft rejection in mouse models of heart transplantation using strains representing both major histocompatibility complex (MHC) (BALB/c to CBA/Ca) and minor histocompatibility complex (mHC) (B10.BR to CBA/Ca) antigen mismatches. CD134 upregulation on in vitro alloactivated T cells was delayed compared with CD69 and CD25, and inhibition of T-cell proliferation was critically dependent on the timing of OX40-Ig administration. Heart allograft survival in a fully allogeneic, MHC-mismatched strain combination was not influenced by CD134 blockade alone, but OX40-Ig treatment in the mHC-mismatched model resulted in long-term graft survival (median survival time extended from 14 days to >100 d...Continue Reading

References

May 1, 1995·The Journal of Experimental Medicine·M H SayeghL A Turka
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·W W HancockL A Turka
Aug 27, 1997·Transplantation·J J CaseyJ A Bradley
Jan 19, 2000·The Journal of Experimental Medicine·K MurataK Sugamura
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I GramagliaM Croft
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·X G SmithJ A Bradley
Nov 9, 2000·European Journal of Immunology·T YoshiokaK Okumura
Mar 13, 2001·Annual Review of Immunology·B Salomon, J A Bluestone
Jul 27, 2001·Journal of Immunological Methods·L Taylor, H Schwarz
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas R JonesChristian P Larsen
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xueli YuanMohamed H Sayegh

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Citations

Mar 26, 2009·Nature Reviews. Immunology·Michael Croft
Aug 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Benjamin WildeOliver Witzke
Aug 19, 2007·Transplantation·Jessamyn BagleyJohn Iacomini
Nov 7, 2012·Transplantation·Gillian KinnearKathryn J Wood
Jul 20, 2010·Immunotherapy·Bert VerbinnenJan L Ceuppens
Sep 11, 2007·The Journal of Hand Surgery·Aurèle TaiebW P Andrew Lee
May 12, 2009·Immunological Reviews·Michael CroftPejman Soroosh
Nov 21, 2007·European Journal of Immunology·Takaaki HattoriMasaru Takeuchi
Aug 22, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Renaud SnanoudjBernard Charpentier
Jul 20, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W GeH Wang
Nov 23, 2017·Frontiers in Immunology·Lin YanCarla C Baan
Jul 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gillian KinnearNick D Jones
Jul 23, 2019·Transplantation Reviews·R Laguna-GoyaE Paz-Artal
Jul 9, 2021·JCI Insight·Toshihito HiraiSanjiv S Gambhir

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