Oxalate excretion during the first 7 weeks in very-low-birth-weight infants

Biology of the Neonate
J Sonntag, J Schaub

Abstract

To determine reference values, we studied urinary excretion of oxalate prospectively and longitudinally in a cohort of 23 very-low-birth-weight (VLBW) infants. The urinary oxalate concentrations were evaluated in 24-hour urine samples by the oxalate oxidase method. Urine samples were obtained at 1, 2-3, 4-5 and 6-7 weeks of age. The median oxalate amount was 24 mumol/kg body weight/day with a 10th-90th percentile range of 16-45 in the 1st week. Oxalate excretion was highest in 2- to 3-week-old infants (median: 35; percentile range: 26-56 mumol/kg body weight/day). In the 4th-5th week, the median was 24 (percentile range: 15-47) mumol/kg body weight/day and in weeks 6-7 also 24 (percentile range: 10-36) mumol/ kg body weight/day. Also, the urinary oxalate concentration as well as the oxalate-creatinine ratio showed increased values in the first 3 weeks of life and decreased values afterwards. In a multivariate analysis, nutrition or gestational age did not affect the urinary oxalate concentration, the daily amount excreted or the oxalate-creatinine ratio. The investigated parameters (oxalate amount and oxalate-creatinine ratio in urine) were significantly age dependent). The data show that urinary oxalate excretion in VLBW infan...Continue Reading

Citations

May 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasileios GiaprosStyliani Andronikou
Dec 11, 2008·Journal of Inherited Metabolic Disease·S IllsingerA M Das
Oct 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·A NarendraJ Beattie
May 17, 2003·European Journal of Pediatrics·Vasilios I GiaprosStyliani K Andronikou
Nov 6, 2002·Journal of Biomedical Materials Research·Charley A MalpassLaurie B Gower

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