Dec 7, 2019

Oxalate nephropathy is a major cause of kidney injury in surgically treated pancreatic adenocarcinoma patients

Clinical Kidney Journal
Geoffroy DesbuissonsLucile Mercadal


Despite new therapeutics, the prognosis for pancreatic cancer remains poor. Pancreatic surgery is a therapeutic option in non-metastatic forms. The consequences for renal function are poorly described. Patients who underwent surgery for pancreatic cancer between 1 January 2010 and 1 January 2017 and who experienced kidney biopsy in the Pitié-Salpêtrière Hospital were analysed. Two hundred and ninety-four patients had pancreatic surgery during the period of analysis and five of them had a kidney biopsy (mean ± SD 20 months ±13.6 months after surgery) during the post-operative follow-up. Among these patients, three exhibited oxalate nephropathy (ON), indicating that the prevalence of ON in patients with pancreatectomy is at least 1%. ON may be insidious, with chronic renal failure without urinary abnormalities. All patients had a high oxalate-to-creatinine ratio in urine sample. Renal function improved after specific management of ON in two patients. Pancreaticoduodenectomy may represent a higher risk of ON than left pancreatectomy. Although rare and underestimated, ON appears to be a real risk after pancreatic resection. Early detection may preserve renal function.

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Mentioned in this Paper

Pancreatic Carcinoma
Kidney Failure, Chronic
Injury of Kidney
Disease Management

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