Dec 7, 2019

Oxalate nephropathy is a major cause of kidney injury in surgically treated pancreatic adenocarcinoma patients

Clinical Kidney Journal
Geoffroy DesbuissonsLucile Mercadal

Abstract

Despite new therapeutics, the prognosis for pancreatic cancer remains poor. Pancreatic surgery is a therapeutic option in non-metastatic forms. The consequences for renal function are poorly described. Patients who underwent surgery for pancreatic cancer between 1 January 2010 and 1 January 2017 and who experienced kidney biopsy in the Pitié-Salpêtrière Hospital were analysed. Two hundred and ninety-four patients had pancreatic surgery during the period of analysis and five of them had a kidney biopsy (mean ± SD 20 months ±13.6 months after surgery) during the post-operative follow-up. Among these patients, three exhibited oxalate nephropathy (ON), indicating that the prevalence of ON in patients with pancreatectomy is at least 1%. ON may be insidious, with chronic renal failure without urinary abnormalities. All patients had a high oxalate-to-creatinine ratio in urine sample. Renal function improved after specific management of ON in two patients. Pancreaticoduodenectomy may represent a higher risk of ON than left pancreatectomy. Although rare and underestimated, ON appears to be a real risk after pancreatic resection. Early detection may preserve renal function.

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Mentioned in this Paper

Urine
Follow-up
Pancreatic Carcinoma
Pancreaticoduodenectomy
Oxalates
PPY
Kidney Failure, Chronic
Injury of Kidney
Disease Management
Analysis

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