Oxaliplatin-Based Chemotherapy in Advanced Neuroendocrine Tumors: Clinical Outcomes and Preliminary Correlation with Biological Factors

Neuroendocrinology
Francesca SpadaNicola Fazio

Abstract

The role of chemotherapy in low-/intermediate-grade neuroendocrine tumors (NETs) is still debated. We present the results of an Italian multicenter retrospective study evaluating activity and toxicity of oxaliplatin-based chemotherapy in patients with advanced NETs. Clinical records from 5 referral centers were reviewed. Disease control rate (DCR) corresponding to PR + SD (partial response + stable disease) at 6 months, progression-free survival (PFS), overall survival (OS) and toxicity were calculated. Ki67 labeling index, grade of differentiation and excision- repair-cross-complementing group 1 (ERCC-1) were analyzed in tissue tumor samples. Seventy-eight patients entered the study. Primary sites were: pancreas in 46, gastrointestinal in 24, lung in 19 and unknown in 10% of patients. The vast majority were G2 (2010 WHO classification). Eighty-six percent of the patients were metastatic, and 87% were pretreated and progressive to previous therapies. Sixty-five percent of the patients received capecitabine/oxaliplatin (CAPOX), 6% gemcitabine/oxaliplatin (GEMOX), and 29% leucovorin/fluorouracil/oxaliplatin (FOLFOX-6). PR occurred in 26% of the patients, half of them with pancreatic NETs, and SD in 54%. With a median follow-up of...Continue Reading

Citations

Apr 9, 2020·Frontiers in Pharmacology·Jiabei ZhouLushan Yu
Nov 26, 2019·Expert Opinion on Pharmacotherapy·Steven D ScovilleTimothy M Pawlik
Jul 28, 2019·Current Treatment Options in Oncology·Mauro CivesFranco Silvestris
Jun 19, 2020·Journal of Clinical Medicine·Lola-Jade PalmieriRomain Coriat
Jan 13, 2021·Medicine·Burcin ÖzdirikBertram Wiedenmann
Dec 29, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Víctor Rodriguez-FreixinosSimron Singh
Jan 23, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E BaudinUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Feb 11, 2021·Pancreas·Alessandra PulvirentiDiane L Reidy-Lagunes
Apr 13, 2021·Reviews in Endocrine & Metabolic Disorders·Paula Espinosa-OlarteRocio Garcia-Carbonero
Mar 3, 2019·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Annie LemelinUNKNOWN MGMT-NET investigators

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