Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation.

Brain and Behavior
Toru KonoKazuo Matsubara

Abstract

Oxaliplatin-induced peripheral neurotoxicity (OPN) is commonly associated with peripheral hypersensitivity to cold sensations (CS) but the mechanism is unknown. We hypothesized that the transient receptor potential melastatin 8 (TRPM8), a putative cold and menthol receptor, contributes to oxaliplatin cold hypersensitivity. To determine whether the TRPM8 is involved in acute OPN, varying concentrations of menthol were topically applied to the tongues of healthy subjects (n = 40) and colorectal cancer patients (n = 36) before and after oxaliplatin administration. The minimum concentration of menthol to evoke CS at the menthol application site was determined as the CS detection threshold (CDT). In healthy subjects, the mean CDT was 0.068. Sex and age differences were not found in the CDT. In advanced colorectal cancer patients, the mean CDT significantly decreased from 0.067% to 0.028% (P = 0.0039) after the first course of oxaliplatin infusions, and this marked CS occurred in patients who had grade 1 or less neurotoxicity, and grade 2 neurotoxicity, but not in those with grade 3 neurotoxicity. Further, the mean baseline CDT in oxaliplatin-treated patients was significantly higher than that of chemotherapy-naïve patients and healt...Continue Reading

References

Dec 3, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E RaymondE Cvitkovic
Sep 30, 2000·European Journal of Pharmacology·H AdelsbergerC Lersch
Mar 15, 2002·Cell·Andrea M PeierArdem Patapoutian
Aug 7, 2003·Seminars in Radiation Oncology·Andy TrottiPhilip Rubin
Sep 11, 2003·Current Opinion in Neurobiology·Sven-Eric JordtDavid Julius
Oct 3, 2003·Seminars in Oncology·Axel Grothey
May 17, 2005·Brain Research. Molecular Brain Research·Junji AbeShigeo Kobayashi
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rodolfo MadridFélix Viana
Aug 21, 2007·Molecular Pain·Richard L Daniels, David D McKemy
Aug 31, 2007·Chemical Senses·Kelly C AlbinE Carstens
Jan 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ajay DhakaArdem Patapoutian
Mar 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence GamelinAimery de Gramont
May 13, 2008·Trends in Neurosciences·Karel TalaveraThomas Voets
Jun 7, 2008·The Journal of Physiology·Rachelle Gaudet
Jan 14, 2009·Journal of Negative Results in Biomedicine·Amir BroomandFredrik Elinder
Apr 18, 2009·British Journal of Pharmacology·Paul J WrigleyChristopher W Vaughan
Aug 6, 2009·Handbook of Experimental Pharmacology·S R Eid, D N Cortright
Oct 20, 2009·Cell·Allan I BasbaumDavid Julius

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Citations

Jan 25, 2016·Journal of Cancer Research and Clinical Oncology·Zhaoguo LiuYin Lu
May 27, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Y-L HsiehC-C Yang
Aug 22, 2013·European Journal of Pain : EJP·H H AndersenL Arendt-Nielsen
Aug 22, 2014·Lancet Neurology·Troels S Jensen, Nanna B Finnerup
Oct 16, 2014·Biochemical Pharmacology·Kathleen YinRichard J Lewis
Jul 21, 2016·Journal of Medicinal Chemistry·M Jesús Pérez de VegaRosario González-Muñiz
Dec 25, 2016·British Journal of Pharmacology·Naomi ItoHidenori Suzuki
Aug 30, 2017·World Journal of Clinical Oncology·Ozkan KanatBurcu Caner
Aug 16, 2014·The Journal of Pharmacology and Experimental Therapeutics·Wendy J WinchesterDavid S Reynolds
Nov 11, 2019·International Journal of Molecular Sciences·Carmen De CaroRoberto Russo
Mar 30, 2017·Scientific Reports·Stephan W HohmannMarco Sisignano
Jun 26, 2018·Journal of Medicinal Chemistry·Alessia BertaminoIsabel Gomez-Monterrey
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Anna FurgałaKinga Sałat

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