Oxalobacter formigenes produces metabolites and lipids undetectable in oxalotrophic Bifidobacterium animalis.

Metabolomics : Official Journal of the Metabolomic Society
Casey A ChamberlainTimothy J Garrett

Abstract

In the search for new potential therapies for pathologies of oxalate, such as kidney stone disease and primary hyperoxaluria, the intestinal microbiome has generated significant interest. Resident oxalate-degrading bacteria inhabit the gastrointestinal tract and reduce absorption of dietary oxalate, thereby potentially lowering the potency of oxalate as a risk factor for kidney stone formation. Although several species of bacteria have been shown to degrade oxalate, select strains of Oxalobacter formigenes (O. formigenes) have thus far demonstrated the unique ability among oxalotrophs to initiate a net intestinal oxalate secretion into the lumen from the bloodstream, allowing them to feed on both dietary and endogenous metabolic oxalate. There is significant interest in this function as a potential therapeutic application for circulating oxalate reduction, although its mechanism of action is still poorly understood. Since this species-exclusive, oxalate-regulating function is reported to be dependent on the use of a currently unidentified secreted bioactive compound, there is much interest in whether O. formigenes produces unique biochemicals that are not expressed by other oxalotrophs which lack the ability to transport oxalat...Continue Reading

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Feb 12, 2019·Analytical and Bioanalytical Chemistry·Casey A ChamberlainTimothy J Garrett
Oct 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Casey A ChamberlainTimothy J Garrett

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Citations

Jun 3, 2021·Metabolites·Casey A ChamberlainTimothy J Garrett
Jul 1, 2021·Applied and Environmental Microbiology·Steven L DanielJohn Knight

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Methods Mentioned

BETA
PCA

Software Mentioned

CEU Mass Mediator
Xcalibur Workstation
RawConverter
MetaboAnalyst

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