Oxalobacter sp. reduces urinary oxalate excretion by promoting enteric oxalate secretion

Kidney International
M HatchR W Freel

Abstract

The primary goal of this study was to test the hypothesis that Oxalobacter colonization alters colonic oxalate transport thereby reducing urinary oxalate excretion. In addition, we examined the effects of intraluminal calcium on Oxalobacter colonization and tested the hypothesis that endogenously derived colonic oxalate could be degraded by lyophilized Oxalobacter enzymes targeted to this segment of the alimentary tract. Oxalate fluxes were measured across short-circuited, in vitro preparations of proximal and distal colon removed from Sprague-Dawley rats and placed in Ussing chambers. For these studies, rats were colonized with Oxalobacter either artificially or naturally, and urinary oxalate, creatinine and calcium excretions were determined. Colonized rats placed on various dietary treatment regimens were used to evaluate the impact of calcium on Oxalobacter colonization and whether exogenous or endogenous oxalate influenced colonization. Hyperoxaluric rats with some degree of renal insufficiency were also used to determine the effects of administering encapsulated Oxalobacter lysate on colonic oxalate transport and urinary oxalate excretion. We conclude that in addition to its intraluminal oxalate-degrading capacity, Oxalob...Continue Reading

References

Dec 14, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Hatch
Aug 1, 1987·Applied and Environmental Microbiology·S L DanielM J Allison
Oct 1, 1980·Applied and Environmental Microbiology·K A DawsonP A Hartman
Mar 29, 2000·Archives of Disease in Childhood·T J NeuhausE Leumann
Oct 10, 2002·American Journal of Nephrology·Marguerite Hatch, Robert W Freel
May 22, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuo MikamiHaruo Ito
Sep 11, 2003·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·R D MittalM Bhandari
Jul 15, 2004·The Journal of Laboratory and Clinical Medicine·Anastasia H HarrisMarguerite Hatch
Nov 27, 2004·Urological Research·Marguerite Hatch, Robert W Freel

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Citations

Jun 20, 2008·Urological Research·Robert W Freel, Marguerite Hatch
Jun 27, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tadeusz PorowskiHalina Porowska
May 15, 2013·Current Rheumatology Reports·Elizabeth C LorenzJohn C Lieske
Jun 5, 2008·Nature Clinical Practice. Nephrology·Susan R Marengo, Andrea M P Romani
Jun 13, 2012·Nature Reviews. Nephrology·Bernd Hoppe
Oct 24, 2013·Journal of Endourology·Jodi A AntonelliMargaret S Pearle
Apr 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bernd HoppeDawn Milliner
Dec 18, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marguerite HatchRobert W Freel
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·David W KaufmanDavid R Cave
Jul 9, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Claire CarteryPatrick Giraud
Nov 22, 2012·Expert Opinion on Investigational Drugs·Bodo B BeckBernd Hoppe
Nov 30, 2015·Urolithiasis·David S Goldfarb
Dec 10, 2015·Urolithiasis·John R Asplin
Feb 27, 2013·Advances in Chronic Kidney Disease·Ita P Heilberg, David S Goldfarb
Sep 8, 2006·Kidney International·B B Beck, B Hoppe
Dec 17, 2008·Kidney International·Khashayar Sakhaee
Sep 22, 2006·Kidney International·D Milliner
Mar 29, 2013·Kidney International·Roswitha SienerAlbrecht Hesse
Aug 26, 2011·Kidney International·Stef RobijnAnja Verhulst
Jun 4, 2013·Kidney International·Ognen Ivanovski, Tilman B Drüeke
Feb 20, 2009·Kidney International·Bernd HoppeDawn S Milliner
Aug 21, 2015·The Journal of Urology·Clea BarnettMartin J Blaser
Jul 9, 2010·Journal of the American College of Surgeons·Branden G DuffeyManoj Monga
Feb 6, 2009·Veterinary Microbiology·J Scott Weese, Amanda Palmer
Dec 20, 2008·Advances in Chronic Kidney Disease·David S Goldfarb
Nov 18, 2008·The Journal of Urology·Bhavin N PatelDean G Assimos
Nov 27, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F BruyereE Lechevallier
May 27, 2008·Journal of the American College of Surgeons·Branden G DuffeyManoj Monga
Mar 25, 2008·Seminars in Nephrology·Marguerite Hatch, Robert W Freel
Mar 25, 2008·Seminars in Nephrology·John C LieskeMaria L Collazo-Clavell
Sep 18, 2007·The Journal of Urology·Sergey ProkopovichRoss P Holmes
Jun 28, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bernd HoppeBodo B Beck
Nov 22, 2008·BJU International·Siddharth SivaMahendra Bhandari
Mar 6, 2013·Seminars in Dialysis·Ruben PoesenPieter Evenepoel

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