Oxamides as novel NR2B selective NMDA receptor antagonists

Bioorganic & Medicinal Chemistry Letters
Gizella Barta-SzalaiGyörgy Domány

Abstract

A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.

Citations

Sep 20, 2008·Journal of Medicinal Chemistry·Yesim A TahirovicJames P Snyder
Jul 28, 2010·Molecular Pharmacology·Kasper B HansenStephen F Traynelis
May 19, 2012·Molecular Pharmacology·Pieter B BurgerStephen F Traynelis
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Mar 24, 2011·Future Medicinal Chemistry·Elena ColomboPaolo Pevarello
Jul 19, 2006·Drug Discovery Today·György M Keseru, Gergely M Makara
Oct 13, 2017·Chemistry : a European Journal·Nicola PiensMatthias D'hooghe
Mar 28, 2013·Chembiochem : a European Journal of Chemical Biology·Martine DhillyCécile Perrio
Nov 19, 2010·Beilstein Journal of Organic Chemistry·Janja MakarevićMladen Zinić

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