Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators

Experientia
F AwoutersP A Janssen

Abstract

Oxatomide is a new potent inhibitor of anaphylactic and allergic reactions. After oral administration, the compound both inhibits the release of endogenous histamine and prevents the effects of exogensous histamine, at comparable doses. The combination of these effects appears to be the basis of the effectiveness of oxatomide in allergic reactions and may lead to clinical application different from classical antihistaminics and from cromoglycate.

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Related Concepts

Histamine Measurement
Immediate Hypersensitivity
Piperazines
Ileum
Oxatomide
Antihistamines, Classical
Anaphylaxis
Cromoglycate
Allergy Testing Histamine (Lab Test)
Histamine

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