Oxatomide: inhibition and stimulation of histamine release from human lung and leucocytes in vitro

Agents and Actions
M K Church, C F Gradidge

Abstract

Oxatomide is a very potent inhibitor of histamine release induced by anti-1gE and Timothy pollen extract in passively sensitized human lung fragments and that induced by anti-1gE from human leucocytes. Its spectrum of activity is different from sodium cromoglycate-like drugs. In high concentrations oxatomide, like other antihistamines and related structures, induced histamine release from both lung and leucocytes. However, oxatomide induced histamine release far more effectively from sensitized lung than non-sensitized lung. Inhibition of immunologically induced histamine releast by oxatomide may play a part in its action as an anti-hay fever and, possibly, an anti-asthmatic drug.

References

Jan 1, 1978·International Archives of Allergy and Applied Immunology·M BorgersP A Janssen
Dec 1, 1978·Agents and Actions·F De ClerckF Awouters
Oct 1, 1977·Agents and Actions·J AugsteinP Sheard
Apr 8, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·D P EvansD S Thomson
Aug 1, 1980·British Journal of Pharmacology·M K Church, C F Gradidge

Citations

Apr 1, 1982·Agents and Actions·A TrunehF L Pearce
Jan 1, 1982·Pharmacology & Therapeutics·R J Davies, I Moodley
Jul 1, 1983·Clinical Allergy·M F D'SouzaJ Goldschmidt
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·J D VeldhuisB J Carroll

Related Concepts

Tinset
Antihistamines, Classical
Histamine Release
Variolation
Leukocytes
Lung
Piperazines
In Vitro [Publication Type]

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