PMID: 3319537Nov 1, 1987Paper

Oxcarbazepine (GP 47.680): a possible alternative to carbamazepine?

Epilepsia
M A HoutkooperJ A Hulsman

Abstract

A double-blind randomized crossover design trial of carbamazepine (CBZ) and oxcarbazepine (OCBZ) was performed with 48 in-patients with epilepsy. All were stabilized on polytherapy including CBZ and had at least two seizures per week. CBZ was replaced by the trial medication. Each trial period started with a titration, followed by a 12-week steady state. Concomitant medications were kept constant during the trial. The criteria for assessment were seizure fit frequency and severity; tolerability; hematology and blood chemistry; plasma levels of antiepileptic drugs; EEG; cardiovascular parameters; and treatment preference. The following differences regarding OCBZ were detected: 9% reduction of the total number of seizures, with a significant reduction of tonic-clonic (20%) and tonic (31%) seizures; increased alertness and concentration ability in five patients; an allergic skin reaction with CBZ that completely disappeared in two patients while receiving OCBZ; an increase of valproate and phenytoin plasma levels in a number of patients, probably caused by reduced enzyme induction; a slight but significant reduction of serum Na, not causing clinical symptoms; less seizures than in the CBZ period in 25 patients (52%); and a prefere...Continue Reading

References

Jan 1, 1982·European Journal of Clinical Pharmacology·M Theisohn, G Heimann

❮ Previous
Next ❯

Citations

Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J M Pellock, L D Morton
Jan 1, 1990·European Journal of Clinical Pharmacology·P N PatsalosA A Elyas
Jan 1, 1993·European Journal of Clinical Pharmacology·H V Curran, R Java
Jan 1, 1995·Pharmacology & Therapeutics·B Rogvi-Hansen, L Gram
Mar 1, 1992·Epilepsy Research·B J SteinhoffW Paulus
Jul 22, 1989·Lancet
Feb 19, 2003·Journal of Affective Disorders·Jonathan S E Hellewell
Jul 6, 2000·Archives of Medical Research·D F González-EsquivelH Jung-Cook
Jun 25, 1999·Progress in Neurobiology·P GareriG De Sarro
May 19, 2001·Neurologic Clinics·K D Holland
Jul 10, 1998·Epilepsy Research·P BorusiakH E Boenigk
Mar 1, 1995·Seizure : the Journal of the British Epilepsy Association·J P Leach, M J Brodie
Jan 1, 1991·British Journal of Clinical Pharmacology·J G LarkinM J Brodie
Jan 1, 1995·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A Sabers, L Gram
Jan 1, 1992·Epilepsia·M J Brodie
Jan 1, 1994·Epilepsia·P LloydW Dieterle
Jan 1, 1994·Epilepsia·L Gram
Jan 1, 1994·Epilepsia·M J McLeanK F Feldmann
Oct 26, 1999·Epilepsia·E S Tecoma
Sep 4, 1999·Contact Dermatitis·V ConilleauD Leroy
Apr 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·J M Zakrzewska, P N Patsalos
Nov 23, 2001·Pharmacotherapy·T A Glauser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.