PMID: 9430314Jan 16, 1998Paper

Oxcarbazepine in the treatment of early childhood epilepsy

Journal of Child Neurology
E GailyE Liukkonen

Abstract

Very little data are available on the usefulness of oxcarbazepine in young children with epilepsy. From January 1991 through October 1994, we treated 53 children under age 7 years with oxcarbazepine. The mean follow-up with oxcarbazepine treatment was 13 months. Etiology was symptomatic in 39, cryptogenic in 12, and idiopathic in 2 children. Forty-three children had previously been intractable to one or more antiepileptic drugs (including carbamazepine in 30 patients) and two had carbamazepine hypersensitivity. The age at onset of oxcarbazepine therapy ranged from 0.6 to 6.9 years (mean, 3.9 yr). The mean maximum oxcarbazepine dose was 50 mg/kg/day (range, 21-86 mg/kg/day). Of the children with localization-related epilepsy, 12 of 44 (27%) became seizure free and an additional 16 of 44 (36%) had an at least 50% reduction of seizures. Five of nine children with generalized epilepsy also had some benefit but none became seizure free. In the 33 children with at least 50% seizure reduction, the mean effective dose and trough serum level of the active metabolite monohydroxycarbazepine were 47 mg/kg/day (range, 21-75 mg/kg/day) and 91 micromol/L (range, 42-130 micromol/L), respectively. Efficacy was transient in 4 children; side effe...Continue Reading

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Citations

Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J M Pellock, L D Morton
May 19, 2001·Neurologic Clinics·K D Holland
Mar 27, 2003·Pediatric Neurology·Gul SerdarogluBerrak Sarioglu
Jul 15, 2000·Clinical Neuropharmacology·B F Bourgeois
Oct 26, 1999·Epilepsia·E S Tecoma
Jan 1, 2000·International Journal of Adolescent Medicine and Health·James J Riviello
Jul 2, 2008·Paediatric Drugs·Allison M Chung, Lea S Eiland
Aug 16, 2001·Brain & Development·S J Wallace
Jun 8, 2001·Clinical Therapeutics·M M Kalis, N A Huff
Jul 5, 2005·Expert Opinion on Investigational Drugs·S C Schachter
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P H McCabe
Oct 22, 2004·Journal of Clinical Pharmacology·Elisabeth ReyOlivier Dulac
Sep 26, 2006·Pediatric Neurology·Sanjeev V KothareAgustin Legido
Aug 31, 2006·Pediatric Neurology·Sanjeev V KothareAgustin Legido
Oct 26, 2005·Pediatric Neurology·Ralph S NorthamYvonne Sturm
Jun 14, 2000·Seizure : the Journal of the British Epilepsy Association·S Shorvon
Oct 16, 2016·Expert Opinion on Drug Safety·Xi Lu, Xuefeng Wang
Mar 29, 2002·Journal of Child Neurology·James W Wheless

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