Oxcarbazepine treatment in male epilepsy patients improves pre-existing sexual dysfunction

Acta Neurologica Scandinavica
Gerhard LuefH Stefan

Abstract

To collect data on sexual dysfunction in a larger population of male patients with epilepsy treated with oxcarbazepine in a naturalistic setting. Six hundred seventy-three adult male patients with partial epilepsy in whom monotherapy with oxcarbazepine was indicated were evaluated at baseline and after approximately 12 weeks of treatment with regard to the number of seizures and occurrence of any adverse drug reactions. All patients were questioned regarding their sexual function. Out of 228 patients with pre-existing sexual function impairment at baseline, an improvement was observed in 181 (79.4%) patients, 23 (10.1%) patients experienced no impairment at the final visit. The improvements were more marked in those patients, who were pretreated with enzyme-inducing antiepileptic drugs. No worsening of the sexual dysfunction was observed. Oxcarbazepine was found to have beneficial effects on sexual dysfunction and to be effective and well tolerated in male patients with partial epilepsy.

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Citations

Jun 10, 2011·Expert Review of Neurotherapeutics·Rocco Salvatore CalabròPlacido Bramanti
Nov 13, 2015·Expert Opinion on Drug Safety·Yong Yang, Xuefeng Wang
Oct 13, 2012·The Journal of Sexual Medicine·Rosana Maria ReisLúcia Alves Silva Lara
Mar 23, 2011·Epilepsy & Behavior : E&B·Rocco Salvatore Calabrò
Jan 22, 2010·Epilepsy & Behavior : E&B·Rocco Salvatore CalabròPlacido Bramanti
Aug 16, 2016·The Psychiatric Clinics of North America·Anita H ClaytonJennifer G Votta

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