Oxcarbazepine versus phenytoin monotherapy for epilepsy

The Cochrane Database of Systematic Reviews
M MullerP R Williamson

Abstract

Worldwide, phenytoin is a commonly used antiepileptic drug. Oxcarbazepine is one of the newer antiepileptic drugs and has similar chemical properties to its parent compound carbamazepine. For the new drugs such as oxcarbazepine, it is important to know how they compare with standard treatments. To review the best evidence comparing oxcarbazepine and phenytoin when used as monotherapy in patients with epilepsy. We searched the Cochrane Epilepsy Group's Specialized Register (December 2005), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 3, 2005), and MEDLINE (1966 to November 2005). No language restrictions were imposed. We checked the reference lists of retrieved studies for additional reports of relevant studies. We also contacted pharmaceutical companies to try and identify any unpublished studies. Randomized controlled trials in children or adults with epilepsy. Trials must have included a comparison of oxcarbazepine monotherapy with phenytoin monotherapy. This was an individual patient data review. Two review authors independently assessed trial quality and extracted data. Study authors were contacted for additional information. Outcomes were (a) time on allocated treatment; (b) time...Continue Reading

Citations

Oct 27, 2009·Neurologic Clinics·Linda J Stephen, Martin J Brodie
Oct 24, 2018·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Sarah J NolanAnthony G Marson

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