Oxfordshire community stroke project clinical stroke syndrome and appearances of tissue and vascular lesions on pretreatment ct in hyperacute ischemic stroke among the first 510 patients in the Third International Stroke Trial (IST-3).

Stroke; a Journal of Cerebral Circulation
Adam KobayashiIST-3 Collaborative Group

Abstract

The Oxfordshire Community Stroke Project (OCSP) clinical stroke syndrome classification correlates well with the stroke lesion in established ischemic stroke, but there are few data in patients with hyperacute stroke. We wished to assess whether the OCSP correlated with the site and size of the ischemic lesion and location of cerebral vessel lesion on computed tomography (CT) in hyperacute stroke. Prospective study of ischemic stroke patients presenting within 6 hours of onset in the Third International Stroke Trial (IST-3), a randomized, controlled trial of rt-PA. OCSP syndrome was assigned by a computer-based algorithm. The CT assessment was made by a neuroradiologist blinded to clinical details. We assessed baseline data and CT findings for the first 510 patients; early tissue ischemic changes were present in 329/510 (65%) total anterior circulation syndrome (TACS) - 79%; partial anterior circulation syndrome (PACS) - 57%, lacunar syndrome (LACS) - 40%; posterior circulation syndrome (POCS) - 33%. The site and size of ischemic change on CT was compatible with the clinical syndrome in 79%, 37%, 2%, and 14%, respectively. Assuming that all patients with a normal CT scan will develop an incompatible lesion these numbers reflect...Continue Reading

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Citations

Sep 19, 2009·Regenerative Medicine·Sean I Savitz, Vivek Misra
Mar 19, 2014·Analytical Biochemistry·Alison S DevonshireCarole A Foy
Jun 11, 2011·Pediatric Research·Cesar V Borlongan, Michael D Weiss
Feb 26, 2011·Journal of the Neurological Sciences·P SinghP A McCombe
Jan 23, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Joanna M WardlawPeter A G Sandercock
Jul 13, 2012·Acta Neurologica Scandinavica·A KobayashiA Czlonkowska
Apr 9, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sheng-Feng SungHuey-Juan Lin
May 6, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Beisi JiangQiang Dong
Oct 12, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yuan GaoBernard Yan
Jul 30, 2014·The Cochrane Database of Systematic Reviews·Joanna M WardlawGregory J del Zoppo
Jun 28, 2011·Stroke; a Journal of Cerebral Circulation·Negar AsdaghiKenneth Butcher
Sep 20, 2019·Internal and Emergency Medicine·Sebastiano GiacomozziMaurizio Paciaroni
Dec 11, 2019·Stroke; a Journal of Cerebral Circulation·Magnus ThorénNiaz Ahmed
May 11, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·David GiannandreaUNKNOWN SISIFO collaborators
Apr 10, 2020·Stroke; a Journal of Cerebral Circulation·Francesco ArbaUNKNOWN Third International Stroke Trial Collaborators

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