Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets

American Journal of Hypertension
Vladimír PechD S Majid

Abstract

To examine the hypothesis that NAD(P)H oxidase (Nox)-derived superoxide generation is involved in the development of angiotensin II (ANG II)-induced hypertension, we evaluated the responses to ANG II infusion (65 ng/min; osmotic mini-pump) for 2 weeks in rats treated with or without apocynin (APO) (inhibitor of Nox subunits assembly) in drinking water (12 mmol/L). Rats were grouped according to their diets with varying salt content (normal salt [NS], 0.4%; high salt [HS], 8%; low salt [LS], 0.03%) given during the 2-week experimental period. The variation in salt intake did not alter mean arterial pressure (MAP, recorded via pre-implanted arterial catheter) but showed proportionate levels in urinary excretion rate of Isoprostaglandin(2alpha) (U(ISO)V; NS, 179 +/- 26; HS, 294 +/- 38; LS, 125 +/- 7 ng/kg/24 h). Treatment with ANG II increased MAP proportional to salt intake (NS, 126 +/- 3 to 160 +/- 5; HS, 116 +/- 4 to 184 +/- 5; LS, 125 +/- 1 to 154 +/- 5 mm Hg). However, ANG II increased U(ISO)V only in NS rats (250 +/- 19 ng/kg/24 h) but not in HS or LS rats. In response to ANG II, Nox subunits protein expression increased in HS but not in the NS or LS rats. Apocynin treatment partially ameliorated these changes in Nox protein...Continue Reading

Citations

May 2, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi EndoSadayoshi Ito
Nov 4, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kanchan BhatiaJennifer C Sullivan
Jul 9, 2010·American Journal of Physiology. Renal Physiology·Libor KopkanDewan S A Majid
Dec 8, 2011·Journal of Applied Toxicology : JAT·June ChoiHak Hyun Jung
Sep 6, 2008·Nephrology·Byung-Hyun ParkKeun-Sang Kwon
May 7, 2010·Clinical Pharmacology and Therapeutics·G M KusterH P Brunner-La Rocca
May 18, 2019·Archives of Toxicology·Christina HartmannNicole Schupp
Aug 9, 2013·American Journal of Physiology. Renal Physiology·Curtis WhitingDewan S A Majid
Feb 5, 2008·Toxicology·Yolanda I ChirinoJosé Pedraza-Chaverri

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