Oxidant stress and glioblastoma multiforme risk: serum antioxidants, gamma-glutamyl transpeptidase, and ferritin

Nutrition and Cancer
J A Schwartzbaum, D G Cornwell

Abstract

Case-control studies of serum antioxidants are difficult to interpret, because antioxidants may be altered by the disease under study. However, because glioblastoma multiforme (GBM) is a relatively rare disease, a cohort study would require a large sample observed for many years. In the present case-control pilot study (34 cases and 35 controls), we evaluated the association between serum levels of ascorbic acid (AA) and alpha- and gamma-tocopherol (alpha-T and gamma-T) measured before diagnostic surgery. To control for influence of GBM on serum AA, alpha-T, and gamma-T, we adjusted for oxidant stress indexes (gamma-glutamyl transpeptidase and uric acid) and an acute-phase response index (serum ferritin). When adjusted, AA is inversely related to GBM (p for trend = 0.007). In addition, AA interacts with alpha-T to further reduce GBM risk (test for interaction, p = 0.04). gamma-T is not associated with GBM (p = 0.71). However, gamma-glutamyl transpeptidase (p = 0.004), coenzyme Q (p = 0.01), and ferritin (p = 0.009) are positively and uric acid (p = 0.000) is negatively related to GBM. We conclude that 1) AA and alpha-T are jointly related to GBM after adjustment for GBM-produced oxidant stress and 2) there is a strong associati...Continue Reading

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Citations

Feb 24, 2007·Journal of Neuro-oncology·Jason Y ChangYi-Hong Zhou
Oct 21, 2017·Oncotarget·Jiaqi HuangDemetrius Albanes
Mar 24, 2020·British Journal of Cancer·Heidi Jaksch-BogenspergerNikolaus Bresgen
Nov 21, 2014·Biochimica Et Biophysica Acta·Sylvie LamyBorhane Annabi
Sep 12, 2008·Journal of Agricultural and Food Chemistry·David G Cornwell, Jiyan Ma

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