Oxidant stress in healthy normal-weight, overweight, and obese individuals

Obesity
Louise A BrownTony Ashton

Abstract

This study was undertaken to investigate the association among BMI and lipid hydroperoxide (LH), total antioxidant status (TAS), superoxide dismutase (SOD), and reduced glutathione (GSH). Ninety (n = 90) healthy males and females (n = 23/67) (29 normal weight (BMI: 22.74 +/- 0.25 kg/m(2)), 36 overweight (BMI: 27.18 +/- 0.23 kg/m(2)), and 25 obese (33.78 +/- 0.48 kg/m(2))) participated in the study. Data collected included anthropometric measures, fasting blood glucose, lipid profile, LH, TAS, and enzymatic antioxidants (SOD, and reduced GSH). The results of the study showed that obese individuals had significantly increased LH levels compared to normal-weight individuals (obese vs. normal weight (0.88 +/- 0.05 vs. 0.67 +/- 0.03 micromol/l, P < 0.01)) but the increased levels were not significantly different when compared to the overweight group (obese vs. overweight (0.88 +/- 0.05 vs. 0.79 +/- 0.05 micromol/l)). No other consistent significant differences in TAS, SOD, and GSH were identified between groups. This study concluded that only obesity and not moderate overweight elevates LH levels. Furthermore, the levels of TAS, SOD, and GSH in obesity do not explain the increased LH levels observed in obesity.

References

Aug 1, 1975·FEBS Letters·B Halliwell
Dec 1, 1991·The American Journal of Clinical Nutrition·E Niki
Jan 1, 1989·Free Radical Research Communications·B Halliwell
Jan 1, 1995·World Health Organization Technical Report Series
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·M PráznýJ Hilgertová
Apr 25, 2000·Hypertension·A D DobrianT J Lauterio
Jun 7, 2000·The Journal of Clinical Investigation·T FukaiD G Harrison
Sep 1, 2000·The American Journal of Clinical Nutrition·J WortsmanM F Holick
Sep 1, 2000·The American Journal of Clinical Nutrition·D GallagherY Sakamoto
Dec 19, 2000·Free Radical Biology & Medicine·F S FacchiniR A Stoohs
Mar 10, 2001·Free Radical Research·E Niki
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·H K VincentP J Scarpace
Aug 21, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S O Olusi
Oct 26, 2002·JAMA : the Journal of the American Medical Association·Giovanni DavìCarlo Patrono
Dec 25, 2002·Clinical Biochemistry·Metin OzataI Caglayan Ozdemir
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·John F KeaneyUNKNOWN Framingham Study
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Hideki UrakawaYukihiko Adachi
Feb 20, 2004·Journal of Sports Sciences·Scott K PowersKaryn L Hamilton
May 6, 2004·Medicine and Science in Sports and Exercise·Heather K VincentKevin R Vincent
Oct 7, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D YesilbursaC Jale
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Feb 5, 2005·Medicine and Science in Sports and Exercise·Heather K VincentRandy W Braith
Feb 12, 2005·The Journal of Clinical Endocrinology and Metabolism·Angelika MohnFrancesco Chiarelli
Nov 23, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H K Vincent, A G Taylor

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Citations

Jun 5, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joanna Sladowska-KozłowskaRoman Janas
Aug 6, 2010·Journal of Sports Sciences·Eric SerranoDario Acuna-Castroviejo
May 9, 2012·International Journal of Nephrology·Jinhua TangShougang Zhuang
Jan 31, 2013·Nutrition Journal·Sonia SfarAbdelhamid Kerkeni
Apr 4, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Willibald WonischMeinrad Lindschinger
Feb 14, 2013·Obesity·Matthew J PickloMatthew I Jackson
Mar 27, 2010·Obesity·Laura Di RenzoAntonino De Lorenzo
Jun 7, 2015·International Journal of Biological Macromolecules·Zhengui YanLijiang Ge
Feb 28, 2015·Oxidative Medicine and Cellular Longevity·Niara da Silva MedeirosCaroline Dani
Jul 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hae-In LeeMi-Kyung Lee
Dec 21, 2013·Fertility and Sterility·Elizabeth H RuderMarlene B Goldman
Jun 16, 2016·Antioxidants & Redox Signaling·Schohraya SpahisEmile Levy
Aug 11, 2011·International Archives of Allergy and Immunology·Li-Ling YangTsu-Nai Wang
Nov 6, 2014·Arquivos brasileiros de endocrinologia e metabologia·Masoud RamezanipourSara Seyed Emami
May 24, 2013·International Journal of Molecular Sciences·Isabella SaviniLuciana Avigliano
Jul 19, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Soo Lim, James B Meigs
May 25, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Catherine BisbalAntoine Avignon
Nov 2, 2019·Bioscience Reports·Xiran LinZhiqi Song
May 11, 2017·Revista da Associação Médica Brasileira·Roberta Cattaneo HornTamiris Felippin
Feb 15, 2020·Nutrición hospitalaria·Adriana Rodríguez-San NicolásVíctor Manuel Mendoza-Núñez
Feb 14, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Dušan ParipovićAmira Peco-Antić
Apr 21, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Andrés García-SánchezAlejandra Guillermina Miranda-Díaz
Sep 15, 2017·Oxidative Medicine and Cellular Longevity·Grażyna RowickaMagdalena Chełchowska
Feb 6, 2021·Scientific Reports·Dalal AlkazemiBanan Habra
Jul 3, 2021·Antioxidants·Dominika KanikowskaKatarzyna Korybalska

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