PMID: 8958129Jan 1, 1997Paper

Oxidant/antioxidant balance in isolated glomeruli and cultured mesangial cells

Free Radical Biology & Medicine
P Ruiz-TorresD Rodríguez-Puyol

Abstract

The mechanisms responsible for age-related glomerular sclerosis (GS) have not been clearly identified. The present experiments were aimed at assessing the importance of the oxidant/antioxidant balance in the early stages of this process. For this purpose, the renal function (biochemical and clearance studies), some characteristics of isolated glomeruli, and reactive oxygen production (superoxide anion, hydrogen peroxide) as well as the antioxidant ability (superoxide dismutase, catalase, glutathione peroxidase) of glomeruli and cultured mesangial cells were studied in 3- and 18-month-old Fischer 344 rats (YOUNG and OLD rats, respectively). OLD animals show a normal renal function, increased urine protein excretion, and augmented protein glomerular content, an indirect index of GS. Isolated glomeruli from these rats produced increased amounts of superoxide anion and hydrogen peroxide, and catalase activity was increased. The glomerular thiobarbituric acid-reactive substances (TBARS) content was higher in OLD than in YOUNG animals. Similar results were obtained in cultured mesangial cells. In summary, the present results demonstrate, at an early stage of rat GS development, an association between the functional and structural cha...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Satoh
Aug 28, 1992·Science·E R Stadtman
Mar 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J R Diamond
Oct 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R D Lindeman
Jan 1, 1990·Free Radical Biology & Medicine·J B ShafferP J Del Vecchio
Apr 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R S GoldsteinJ B Hook
Mar 1, 1986·The American Journal of Medicine·S Anderson, B M Brenner
Mar 1, 1985·Kidney International·A RehanR C Wiggins
Aug 1, 1972·American Journal of Clinical Pathology·R P Misra
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Jan 1, 1982·Experimental Gerontology·V K Goyal
Jul 1, 1993·Current Opinion in Nephrology and Hypertension·K J Johnson, J M Weinberg
Feb 1, 1993·Kidney International·C García-EscribanoD Rodríguez-Puyol
Jan 1, 1994·Kidney International·I IchikawaT Yoshioka
Jan 1, 1993·Critical Reviews in Toxicology·J P Kehrer

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Citations

Jul 1, 1998·Age·H Otani, M Mune
Jul 29, 2005·The American Journal of Pathology·Zheng FengGary E Striker
Mar 5, 2003·Free Radical Biology & Medicine·Celia J ReedEdward A Lock
Oct 22, 2004·Kidney International·Virginia Vega-WarnerWilliam E Smoyer
Jan 18, 2013·Oxidative Medicine and Cellular Longevity·Ji Hee LimBum Soon Choi
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jing ChenPaul K Whelton
Apr 30, 2013·Free Radical Biology & Medicine·M Gonzalez-RamosM Rodriguez-Puyol
Mar 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S H LeeC S Lee
Sep 16, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Y Y JangC S Lee
Mar 26, 2003·The American Journal of Pathology·Feng ZhengGary E Striker

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