Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes.

Journal of Cellular Physiology
Alexia EliadesKatya Ravid

Abstract

Reactive oxygen species (ROS), generated as a result of various reactions, control an array of cellular processes. The role of ROS during megakaryocyte (MK) development has been a subject of interest and research. The bone marrow niche is a site of MK differentiation and maturation. In this environment, a gradient of oxygen tension, from normoxia to hypoxia results in different levels of ROS, impacting cellular physiology. This article provides an overview of major sources of ROS, their implication in different signaling pathways, and their effect on cellular physiology, with a focus on megakaryopoiesis. The importance of ROS-generating oxidases in MK biology and pathology, including myelofibrosis, is also described.

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Citations

Mar 29, 2014·IUBMB Life·Marcelo G BoniniAlyssa M Master
Mar 27, 2016·Biochimica Et Biophysica Acta·Zhen YanWeidong Wu
Feb 26, 2015·Journal of Thrombosis and Haemostasis : JTH·K JimenezC Gasche
Feb 12, 2014·Antioxidants & Redox Signaling·Becky A DieboldJ David Lambeth
Oct 19, 2017·International Journal of Molecular Sciences·Fabiana ZoleaFlavia Biamonte
Jul 19, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Abolfazl RazzaghdoustMasoumeh Zangeneh
Apr 2, 2014·Current Opinion in Hematology·Haiyoung Jung, Inpyo Choi
Jan 9, 2020·The Biochemical Journal·Beibei ZhangWadie F Bahou
Sep 24, 2019·Platelets·William Vainchenker, Hana Raslova

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