PMID: 11897854Mar 19, 2002Paper

Oxidation induces a Cl(-)-dependent cation conductance in human red blood cells

The Journal of Physiology
Christophe DurantonFlorian Lang

Abstract

Oxidative stress induces complex alterations of membrane proteins in red blood cells (RBCs) eventually leading to haemolysis. To study changes of membrane ion permeability induced by oxidative stress, whole-cell patch-clamp recordings and haemolysis experiments were performed in control and oxidised human RBCs. Control RBCs exhibited a small cation-selective whole-cell conductance (236 +/- 38 pS; n = 8) which was highly sensitive to the external Cl(-) concentration: replacement of NaCl in the bath by sodium gluconate induced an increase of this cation conductance by about 85 %. Exposing RBCs to t-butylhydroxyperoxide (1 mM for 10 min) induced a twofold increase in this cation conductance which was further stimulated after replacement of extracellular Cl(-) by gluconate, Br(-), I(-) or SCN(-). In addition, lowering the ionic strength of the bath solution by isosmotic substitution of NaCl by sorbitol activated the cation conductance. The Cl(-)-sensitive and oxidation-induced cation conductance was Ca(2+) permeable, exhibited a permselectivity of Cs(+) > K(+) > Na(+) = Li(+) > NMDG(+), and was partially inhibited by amiloride (1 mM) and almost completely inhibited by GdCl(3) (150 microM), but was insensitive to TEA, BaCl(2), NPPB,...Continue Reading

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Citations

Mar 15, 2008·Inflammatory Bowel Diseases·Corinna GeigerFlorian Lang
Oct 26, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Philipp A LangChristophe Duranton
Dec 21, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Ravi S KasinathanFlorian Lang
Dec 20, 2005·The Journal of Membrane Biology·F LangS M Huber
Jul 3, 2009·The Journal of Membrane Biology·Yuliya V KucherenkoFlorian Lang
Jun 8, 2010·The Journal of Membrane Biology·Yuliya V KucherenkoFlorian Lang
Nov 11, 2010·The Journal of Membrane Biology·Yuliya V Kucherenko, Florian Lang
Feb 3, 2009·Annals of Hematology·Sergios GatidisFlorian Lang
Sep 28, 2007·Pflügers Archiv : European journal of physiology·Michael FöllerFlorian Lang
Aug 13, 2008·Pflügers Archiv : European journal of physiology·Canan AkkayaStephan M Huber
Feb 3, 2009·Pflügers Archiv : European journal of physiology·Daniela S KempeFlorian Lang
May 22, 2010·Pflügers Archiv : European journal of physiology·Elisabeth LangFlorian Lang
Sep 22, 2010·Pflügers Archiv : European journal of physiology·Michael FöllerStephan M Huber
May 4, 2004·Blood Cells, Molecules & Diseases·Gaëtan DecherfSerge L Thomas
Jun 29, 2011·Journal of Agricultural and Food Chemistry·Sergios GatidisFlorian Lang
Sep 20, 2011·Journal of Natural Products·Kashif JilaniFlorian Lang
Mar 5, 2005·Cell Death and Differentiation·P A LangS M Huber
Mar 31, 2004·The Journal of General Physiology·Christophe DurantonFlorian Lang
Aug 17, 2006·Antioxidants & Redox Signaling·Florian LangThomas Wieder
Jun 1, 2006·Acta Physiologica·F LangT Wieder
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Qing LiAlan M Krensky
Jun 16, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Karl S LangFlorian Lang
Jul 23, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yuliya KucherenkoJohn S Gibson
Jun 23, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Michael FöllerFlorian Lang
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jan P NicolayFlorian Lang
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ekaterina ShumilinaFlorian Lang
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Astrid StumpfHermann Schillers
Feb 21, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Joseph A BrowningJohn S Gibson
Sep 1, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Philipp AttanasioFlorian Lang
Sep 1, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ingolf BernhardtPoul Bennekou
Jan 23, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Michael FollerStephan M Huber
Jan 23, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Olivier M NiemoellerFlorian Lang
May 6, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Saisudha KokaFlorian Lang
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shefalee K BhavsarFlorian Lang
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Syed M QadriFlorian Lang
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Elisabeth LangFlorian Lang
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Syed M QadriFlorian Lang
May 24, 2011·Malaria Journal·Adil BallalFlorian Lang
May 16, 2009·Malaria Journal·Diwakar BobbalaFlorian Lang
May 13, 2010·Malaria Journal·Ioana AlesutanFlorian Lang
Feb 26, 2013·PloS One·Majed AbedFlorian Lang
Dec 24, 2013·Antioxidants & Redox Signaling·Florian LangMichael Föller
Dec 3, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Manuel BraunFlorian Lang

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