Oxidation of cefalexin by thermally activated persulfate: Kinetics, products, and antibacterial activity change

Journal of Hazardous Materials
Yajie QianQi Wang

Abstract

While the widely used β-lactam antibiotics, such as cephalosporins, are known to be susceptible to oxidation by sulfate radical (SO4-), comprehensive study about SO4--induced oxidation of cephalosporins is still limited, such as the impact of water matrices, and the structure and antibacterial activity of transformation products. Herein, the oxidation of cefalexin (CFX), a most frequently detected cephalosporin, was systematically investigated by thermally activated persulfate (PS). CFX oxidation followed pseudo-first-order kinetics, and SO4- dominantly contributed to the overall oxidation of CFX. The impact of water matrices, such as Cl-, HCO3- and natural organic matter, on CFX degradation was predicted using a pseudo-steady-state kinetic model. The secondary reactive species, such as chlorine and carbonate radicals, were found to contribute to CFX degradation. Product analysis indicated oxidation of CFX to six products (molecular weight of 363), with two stereoisomeric sulfoxides as the primary oxidation products. It was thus suggested that the primary amine on the side chain, and the thioether sulfur and double bond on the six-membered ring were the reactive sites of CFX towards SO4- oxidation. Antibacterial activity assess...Continue Reading

Citations

Feb 5, 2019·Environmental Science and Pollution Research International·Reza ShokoohiAmir Shabanloo
Aug 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yajie QianJiabin Chen
Jun 27, 2019·Environmental Science and Pollution Research International·Xiaodan ZhaoYonggui Yan
May 15, 2021·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Yanrui CuiKaili Ma
Jun 28, 2021·Chemosphere·Xuehong YuanNandong Xue
Sep 17, 2019·Environmental Science & Technology·Jiabin ChenChing-Hua Huang

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