PMID: 36712May 1, 1979

Oxidation of fatty-aromatic aldehydes in liver tissues

Voprosy medit︠s︡inskoĭ khimii
G V Kholmina, V Z Gorkin

Abstract

A protein fraction, which did not contain NADP [or NADPH]-dependent aldehyde reductase as well as NAD [or NADP]-dependent aldehyde dehydrogenases, but which catalyzed oxidation of fatty-aromatic aldehydes, was isolated from extract of rat liver tissue using ammonium sulfate fractionation combined with gradient syvorptive chromatography on DEAE-Sephadex A-25 [or Molselect DEAE-25], CM-Sephadex C-25 and gel-filtration on Sephadex G-200. Investigations of molecular weight and catalytic properties of the protein fraction obtained enabled to identify it with xanthine oxidase [EC 1.2.3.2]. Aldehyde dehydrogenases as well as xanthine oxidase are involved in oxidation of fatty-aromatic aldehydes to corresponding fatty acids, besides the reduction of the aldehydes to alcohols, catalyzed by aldehyde reductase and alcohol dehydrogenases.

Related Concepts

Aldehyde Oxidoreductases
Aldehydes
Catalysis
Enzyme Activation
Liver
NADH
NADP
Oxidation-Reduction
Xanthine Oxidase

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