Oxidation of H2S in mammalian cells and mitochondria

Methods in Enzymology
Abbas Abou-HamdanFrédéric Bouillaud

Abstract

Hydrogen sulfide (H2S) is the third gasotransmitter described in mammals. These gasotransmitters (H2S, CO, and NO) are small molecules able to diffuse freely across membranes and thus susceptible to reach easily intracellular targets, one of which is the respiratory enzyme cytochrome oxidase subject to complete inhibition by low micromolar concentrations of these gases. However in contrast to NO or CO, H2S can be metabolized by a sulfide quinone reductase feeding the mitochondrial respiratory chain with the hydrogen atoms of sulfide. Sulfide is thus a two-sided molecule: substrate or poison according to the concentration. The aim of this chapter is to present a mean to monitor sulfide oxidation by isolated mitochondria or cells and to summarize how the properties of this amazing couple (mitochondria and sulfide) translate into practical and conceptual consequences.

Citations

May 4, 2016·Biochimica Et Biophysica Acta·Abbas Abou-HamdanFrédéric Bouillaud
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Antonia KatsoudaAndreas Papapetropoulos
Mar 7, 2019·Oxidative Medicine and Cellular Longevity·Francesca MalagrinòAlessandro Giuffrè
Jul 28, 2018·Oxidative Medicine and Cellular Longevity·Alessandro Giuffrè, João B Vicente
Nov 3, 2020·Redox Biology·Bindu D PaulKhosrow Kashfi
Dec 19, 2017·Biochemical Pharmacology·Kenneth R Olson
Oct 25, 2017·Biochemical Pharmacology·Ashley A UntereinerCsaba Szabo
Feb 21, 2021·Antioxidants & Redox Signaling·Arno R BourgonjeEd J van Hezik
Jun 3, 2021·Biomolecules·Saadullah KhattakDong-Dong Wu
Jul 3, 2021·Cells·Lukas RoubenneChristelle Guibert
Nov 1, 2017·Chemical Research in Toxicology·Kristin L FrawleyJim Peterson
Jan 11, 2020·Chemical Research in Toxicology·Kristin L FrawleyJim Peterson
Sep 7, 2021·The Journal of Experimental Biology·Birgitte S Jensen, Angela Fago
Sep 15, 2021·European Journal of Clinical Investigation·Inês Mateus, Carina Prip-Buus

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