PMID: 11899467Mar 20, 2002Paper

Oxidation of lincomycin by hydrogen peroxide restricts its potential biotransformation with haloperoxidases

Folia Microbiologica
Stanislav PospísilJ Spizek

Abstract

Lincomycin biotransformation was conducted by using Streptomyces venezuelae and Streptomyces phaeochromogenes cell-free extracts. Reaction products were isolated and identified by MS and NMR spectroscopy as lincomycin sulfoxide and lincomycin sulfone. Both compounds arise also by chemical oxidation with hydrogen peroxide; this reaction represents a new efficient way for the preparation of lincomycin sulfoxide and lincomycin sulfone and simultaneously excludes the biotransformation of lincomycin using haloperoxidases.

References

Jan 1, 1996·Annual Review of Microbiology·K H van Pée
Dec 24, 1997·The Journal of Antibiotics·F SztaricskaiS Omura
May 31, 2001·Archives of Microbiology·K H van Pée

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Citations

Mar 13, 2003·Folia Microbiologica·T Rezanka, J Spizek
Nov 1, 2003·Applied Microbiology and Biotechnology·J Spízek, T Rezanka
Mar 23, 2011·Environmental Science & Technology·Lanhua HuTimothy J Strathmann
Mar 5, 2015·Chemical Society Reviews·Sherif I ElshahawiJon S Thorson

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