PMID: 6978295Dec 1, 1981Paper

Oxidation of methionine by X2.- in aqueous solution and characterization of some S therefore X three-electron bonded intermediates. A pulse radiolysis study

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
K O Hiller, K D Asmus

Abstract

The primary steps of the oxidation of methionine, Met, by X2.- (X = Cl; Br, I, SCN) have been investigated using pulse radiolysis techniques. In principle, the mechanism follows the same pattern which has been established for the OH radical induced oxidation. It is characterized by a primary attack at the sulphur atom and the formation of sulphur-centred radical cations S+. and S therefore (+) S as key intermediates. At pH greater than pKa of the carboxyl group these can then oxidize the amino function intramolecularly, which subsequently leads to irreversible decarboxylation. An additional important intermediate is a S therefore X radical with a three-electron bond between sulphur and halide. This radical is linked to the OH . radical induced mechanism through the equilibrium S therefore X + Met in equilibrium with S therefore (+) S + X-, and in addition exists in the equilibria X2.- + Met in equilibrium with S therefore X + X-, S therefore X in equilibrium with S+. + X- and S therefore X in equilibrium with Met + X.. The S therefore X- species absorb at 410, 400, and 390 nm for X = I, Br, and Cl, respectively. Absolute rate constants have been measured for the reactions S therefore (+) S + I- (k = 1.0 x 10(10) mol-1 ls-1, pH ...Continue Reading

References

Oct 1, 1978·Photochemistry and Photobiology·R H BisbyA K Davies
Sep 17, 1975·Journal of the American Chemical Society·S G Cohen, S Ojanpera

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Citations

Sep 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S AbelidisA Chakravarty
Dec 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·K Bobrowski, R Lubis
Nov 1, 1995·International Journal of Radiation Biology·R F AndersonK B Patel
Oct 24, 2014·The AAPS Journal·Jennifer L FurmanMichael J Hunter
May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kimberly M Parker, William A Mitch
Jul 23, 2016·Environmental Science & Technology·Kimberly M ParkerWilliam A Mitch
Mar 31, 2016·The Biochemical Journal·Michael J Davies
Jan 1, 1986·Free Radical Research Communications·W A PrützA J Swallow
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz PedzinskiPiotr Filipiak
Jun 5, 2021·Environmental Science and Pollution Research International·László Wojnárovits, Erzsébet Takács
Feb 1, 2005·Biochimica Et Biophysica Acta·Michael J Davies
Aug 7, 2018·Environmental Science & Technology·Ke Zhang, Kimberly M Parker

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