Oxidative biodegradation mechanisms of biaxially strained poly(etherurethane urea) elastomers

Journal of Biomedical Materials Research
M A SchubertJ M Anderson

Abstract

As part of ongoing studies in polyurethane biostability and biodegradation, we have investigated an in vitro system to test strained poly(etherurethane urea) (PEUU). Recently, we utilized this system to reproduce in vivo stress cracking in strained Pellethane. In this study, strained PEUU was tested to determine whether it degrades through a common mechanism with Pellethane and to further examine the steps involved in this degradation. Biaxially strained PEUU elastomers were treated with an alpha 2-macroglobulin (alpha 2-Mac) protein solution followed by an oxidative H2O2/CoCl2 treatment. Characterization of the strained PEUU specimens was performed with attenuated total reflectance-Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), electron spectroscopy for chemical analysis, and contact angle analysis. The results from these characterization techniques provide conclusive evidence that biodegradation of PEUU and Pellethane occurs through a common mechanism. Chemical changes to the PEUU include cleavage of the polyether soft segments and urethane linkages, leaving the hard segment domains unaffected. SEM analysis shows that this chain cleavage leads to the development of severe pitting and cracking of ...Continue Reading

References

Mar 1, 1983·Journal of Biomedical Materials Research·R MarchantJ M Anderson
Jan 1, 1994·Journal of Biomaterials Science. Polymer Edition·M RenierC R Payet
Nov 1, 1993·The Journal of Clinical Investigation·K SutherlandJ W Eaton
Mar 1, 1993·Journal of Biomedical Materials Research·G F MeijsK Schindhelm

❮ Previous
Next ❯

Citations

Nov 1, 1996·Journal of Biomedical Materials Research·B J PolA Bantjes
Mar 15, 1997·Journal of Biomedical Materials Research·M A SchubertA Hiltner
Jun 5, 1997·Journal of Biomedical Materials Research·M A SchubertA Hiltner
Jun 25, 1998·Journal of Biomedical Materials Research·T CollierJ Anderson
Jul 9, 1999·Journal of Biomedical Materials Research·L WuG Rosenberg
Dec 20, 2005·Journal of Materials Science. Materials in Medicine·Nicholas P RhodesJohn A Hunt
Apr 22, 2010·Journal of Materials Science. Materials in Medicine·Luigi De NardoSilvia Farè
Dec 4, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·M DadsetanJ M Anderson
May 14, 2003·Biomaterials·Anil ThapaKaren M Haberstroh
Dec 15, 2010·Journal of Biomaterials Science. Polymer Edition·Taeyi ChoiJames Runt
Nov 23, 2001·Journal of Biomaterials Science. Polymer Edition·G A Skarja, K A Woodhouse
Aug 17, 2002·Journal of Biomaterials Science. Polymer Edition·Rosalind S LabowJ Paul Santerre
Feb 12, 2004·Journal of Biomaterials Science. Polymer Edition·M J ErnstingJ P Santerre
Dec 10, 2003·Journal of Biomaterials Science. Polymer Edition·Z G TangM Umezu
Nov 26, 1999·Journal of Biomaterials Science. Polymer Edition·T OhseS Nagaoka
Jun 18, 2014·Regenerative Medicine·Erhan BatAndré A Poot
Dec 19, 2007·Journal of Biomedical Materials Research. Part a·Suresh K JewrajkaFlavius Popescu
Aug 21, 2010·Journal of Biomedical Materials Research. Part a·David CozzensShrojal Desai
May 26, 2004·International Journal of Pharmaceutics·M Acemoglu
Apr 12, 2005·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Theodore Eliades, Christoph Bourauel
Jan 30, 2007·The Annals of Thoracic Surgery·Yosuke IshiiRalph J Damiano
Apr 22, 2015·Journal of Materials Science. Materials in Medicine·Serena BertoldiMaria Cristina Tanzi
Feb 27, 2004·Journal of Biomedical Materials Research. Part a·Michael J WigginsAnne Hiltner
Jul 1, 2004·Journal of Biomedical Materials Research. Part a·Elizabeth M ChristensonAnne Hiltner
Aug 15, 2003·Journal of Biomedical Materials Research. Part a·Michael J WigginsAnne Hiltner
May 23, 2003·Journal of Biomedical Materials Research. Part a·Michael J WigginsAnne Hiltner
May 6, 2004·Journal of Biomedical Materials Research. Part a·Elizabeth M ChristensonAnne Hiltner
Jul 11, 1998·Journal of Biomaterials Science. Polymer Edition·R Yoda
Jun 1, 2006·Journal of Biomedical Materials Research. Part a·Stanley J StachelekRobert J Levy
Mar 6, 2007·Journal of Biomedical Materials Research. Part a·Joanne E McBaneRosalind S Labow
Mar 21, 2007·Journal of Biomedical Materials Research. Part a·Stanley J StachelekRobert J Levy
Feb 17, 2005·Journal of Biomedical Materials Research. Part a·Elizabeth M ChristensonAnne Hiltner
Jul 20, 2007·Journal of Biomedical Materials Research. Part a·Chih-Wei ChouPey-Hwa Wang
Jan 11, 2008·Journal of Biomedical Materials Research. Part a·Rebeca HernandezJames Runt
Dec 14, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Suping LyuJason Krzeszak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.