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Oxidative biotransformation of 2-acetylaminofluorene in fetal and placental tissues of humans and monkeys. Correlations with aryl hydrocarbon hydroxylase activities

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

Mont R JuchauP K Zachariah

PMID: 1224

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Abstract

The mixed-function oxidation of 14C-labled 2-acetylaminofluorene (AAF) was investigated in placental and fetal tissues of humans and monkeys (Macaca nemestrina) in vitro. The major metabolite formed in most tissues was 7-hydroxy-AAF. Rates of the hydroxylation reactions varied widely am...read more

Mentioned in this Paper

Macaca
Platyrrhini
Oxidation-Reduction
CYP1A1 gene
Monkeys
Benzo(a)pyrene
Metabolic Inhibition
Aryl Hydrocarbon Hydroxylases
Anthropoidea
Xenobiotic Monooxygenases
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  • Oxidative biotransformation of 2-acetylaminofluorene in fetal and placental tissues of humans and monkeys. Correlations with aryl hydrocarbon hydroxylase activities

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    Mont R JuchauP K Zachariah

    PMID: 1224

    DOI:

    Abstract

    The mixed-function oxidation of 14C-labled 2-acetylaminofluorene (AAF) was investigated in placental and fetal tissues of humans and monkeys (Macaca nemestrina) in vitro. The major metabolite formed in most tissues was 7-hydroxy-AAF. Rates of the hydroxylation reactions varied widely am...read more

    Mentioned in this Paper

    Macaca
    Platyrrhini
    Oxidation-Reduction
    CYP1A1 gene
    Monkeys

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