Oxidative coupling strategies for the synthesis of indole alkaloids

Chemical Society Reviews
Karre Nagaraju, Dawei Ma

Abstract

Direct bond formation between two C-H bonds is most challenging but imperative for efficient organic synthesis. Recently, significant progress has been made in direct functionalization of indole through oxidative coupling reactions with other nucleophiles such as enolates and phenols. Both intermolecular and intramolecular coupling reactions can be conducted under the action of base/oxidants or oxidants alone. Coupling typically occurs at the 3-position of indole moiety due to intrinsic nucleophilicity at this position. Coupling at the 2- or 4-position of the indole moiety has been observed for some special substrates. These coupling reactions provide powerful tools for quickly establishing the core structures of a number of indole alkaloids.

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Citations

Apr 3, 2020·Organic & Biomolecular Chemistry·Hai-Lei Cui
May 20, 2020·Organic & Biomolecular Chemistry·Hai-Lei Cui
Jun 11, 2020·Organic & Biomolecular Chemistry·Gints Smits, Ronalds Zemribo
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Jul 15, 2020·Organic & Biomolecular Chemistry·Yanni LiXianhao Long
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Aug 13, 2021·Drug and Chemical Toxicology·Ruiying YuanJianqing Yu
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Jan 21, 2020·The Journal of Organic Chemistry·Hanghang WangXiaobing Wan
Jan 13, 2022·Organic & Biomolecular Chemistry·Yingying XueYusheng Wu

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Methods Mentioned

BETA
amidation

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