Oxidative damage and aging: spotlight on mitochondria

Cancer Research
Nancy J LinfordPeter S Rabinovitch

Abstract

Whereas free radical damage has been proposed as a key component in the tissue degeneration associated with aging, there has been little evidence that free radical damage limits life span in mammals. The current research shows that overexpression of the antioxidant enzyme catalase in mitochondria can extend mouse life span. These results highlight the importance of mitochondrial damage in aging and suggest that when targeted appropriately, boosting antioxidant defenses can increase mammalian life span.

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Citations

Dec 4, 2012·Journal of Clinical Monitoring and Computing·Avraham Mayevsky, Efrat Barbiro-Michaely
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Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Jinlong WeiXin Jiang
Nov 17, 2019·Journal of Clinical Medicine·Loredana Moro

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