PMID: 9421189Jan 8, 1998Paper

Oxidative damage of human skin lipids. Dependence of lipid peroxidation on sterol concentration

Biochimica Et Biophysica Acta
J LaschD Beckert

Abstract

Photoprotection against sunburn and associated irradiation-induced damages of the human skin is mainly attributed to the darkening of the biochrome melanin by its oxidation. Human skin lipids were examined for an additional protection by sterols. Lipid vesicles prepared from extracted human skin lipids as well as from mixtures of typical lipids of the stratum corneum were irradiated by UV light in the presence and absence of oxygen. The oxidative degradation of various lipids was measured by quantitative HPTLC, by the dichlorofluorescein fluorescent assay, by the thiobarbituric acid assay and a novel luminol-based chemiluminescence technique. Electron spin resonance was used to look for certain radical intermediates. The results indicate, that sterols, mainly free cholesterol, with their high concentration in the lipid barrier of the stratum corneum (up to 50 mol%) effectively compete with the peroxidation of other human skin lipids (ceramides and free fatty acids).

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Citations

Mar 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C A RyanG F Gerberick
May 10, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H TrommerR H Neubert
Oct 25, 2013·International Journal of Cosmetic Science·D R HoffmanD W Koenig
Mar 6, 2004·Drug Development and Industrial Pharmacy·Linda A FeltonDonald A Godwin
Jan 13, 2015·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·D R HoffmanD W Koenig
Mar 14, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R M Brand, J L Jendrzejewski
Sep 3, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Donald A GodwinLinda A Felton
Mar 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Xinxing ZhangJ L Beauchamp
Oct 7, 2020·Antioxidants·Sapir Ron-Doitch, Ron Kohen
Oct 5, 2020·Free Radical Biology & Medicine·Anke SchmidtSander Bekeschus
Aug 30, 2021·The Journal of Investigative Dermatology·Norihiro FujimotoShingo Tajima
Nov 1, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·S SchalkaM S Baptista

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