Oxidative damage to membrane lipids in the thyroid - no differences between sexes.

Drug and Chemical Toxicology
Jan StepniakMalgorzata Karbownik-Lewinska

Abstract

It has long been observed that thyroid diseases are more prevalent in women than in men. However, there are limited experimental data demonstrating mechanisms by which sex differences in thyroid diseases may occur and exact molecular mechanisms involved are still far from clear. The aim of the study was to evaluate if there are sex differences concerning oxidative damage to membrane lipids in thyroid homogenates in response to Fenton reaction substrates, i.e., Fe2+ and/or H2O2, and, additionally, in response to potentially protective agent, i.e., melatonin. Homogenates of male or female thyroids collected from adult swine (Sus scrofa domesticus) at slaughter were incubated in the presence of H2O2 and/or Fe2+ without or with addition of melatonin. Malondialdehyde + 4-hydroxyalkenals concentration (LPO index) was measured spectrophotometrically. Neither H2O2 nor Fe2+, when used separately, did affect the level of lipid peroxidation in both male and female porcine thyroid homogenates. When H2O2 (0.5 mM) was used together with different concentrations of Fe2+, the level of lipid peroxidation increased significantly in both male and female porcine thyroid homogenates, with clear Fe2+ concentration-dependent stimulatory effect, but w...Continue Reading

References

Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Joseph G HollowellLewis E Braverman
Oct 31, 2003·Journal of Cellular Biochemistry·Małgorzata Karbownik, Andrzej Lewiński
Nov 25, 2004·The Journal of Biological Chemistry·Dantong WangFrançoise Miot
Jul 18, 2006·Free Radical Biology & Medicine·Marilyn Ehrenshaft, Ronald P Mason
Aug 2, 2007·The Journal of Clinical Endocrinology and Metabolism·Y SongJ E Dumont
Jan 27, 2009·The Journal of Endocrinology·Sylvie PoncinAnne-Catherine Gérard
Dec 15, 2010·Future Oncology·Reza RahbariElectron Kebebew
Jan 10, 2012·Thyroid : Official Journal of the American Thyroid Association·Sara J SchonfeldAlina V Brenner
Feb 4, 2012·Molecular Endocrinology·Helmut GrasbergerSamuel Refetoff
Oct 2, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jan StępniakMałgorzata Karbownik-Lewińska
Oct 5, 2012·Thyroid : Official Journal of the American Thyroid Association·Rodrigo Soares FortunatoDenise P Carvalho
Oct 24, 2012·Cancer Causes & Control : CCC·Geoffrey C KabatThomas E Rohan
Dec 27, 2012·Thyroid Research·Małgorzata Karbownik-LewińskaAndrzej Lewiński
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Ane Garmendia MadariagaJuan C Galofré
Nov 10, 2014·European Journal of Nutrition·Malgorzata Karbownik-LewinskaAndrzej Lewinski
Dec 19, 2015·Systems Biology in Reproductive Medicine·Jan Stepniak, Malgorzata Karbownik-Lewinska
Feb 6, 2017·Molecular and Cellular Endocrinology·Denise P Carvalho, Corinne Dupuy
Apr 20, 2017·International Journal of Molecular Sciences·Russel J ReiterKexin Xu
Aug 11, 2017·Cellular and Molecular Life Sciences : CMLS·Zhiqiang MaYang Yang
Apr 7, 2018·Cancer Causes & Control : CCC·Benjamin C JamesBriseis Aschebrook-Kilfoy
Dec 19, 2018·International Journal of Molecular Sciences·Jan StepniakMalgorzata Karbownik-Lewinska

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Citations

Sep 24, 2020·International Journal of Environmental Research and Public Health·Aleksandra RynkowskaMałgorzata Karbownik-Lewińska

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